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master's thesis
Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:601804
Milošević, Ivana
University of Zagreb
School of Medicine
Department of Pathology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Milošević, I. (2019). Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:601804

Milošević, Ivana. "Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:601804

Milošević, Ivana. "Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:601804

Milošević, I. (2019). 'Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa', Master's thesis, University of Zagreb, School of Medicine, accessed 05 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:601804

Milošević I. Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 05] Available at: https://urn.nsk.hr/urn:nbn:hr:105:601804

I. Milošević, "Imunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:601804

Metadata
TitleImunohistokemijska izraženost proteina BORIS i STAM-2 u tumorima zametnih stanica testisa
Title (english)Immunohistochemical expression of BORIS and STAM-2 in testicular germ cell tumours
AuthorIvana Milošević
MentorBožo Krušlin (mentor)
Committee memberDavor Tomas (predsjednik povjerenstva)
Committee memberSlavko Gašparov (član povjerenstva)
Committee memberBožo Krušlin (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pathology)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Tumori zametnih stanica testisa su najčešći tumori mladih muškaraca u periodu od puberteta do 40 godina. U Republici Hrvatskoj i Republici Sloveniji se bilježi najveći porast incidencije TGCT-a od svih zemalja Europe. Naglasak ove studije je na skupini seminoma i neseminoma adolescenata i mlađe odrasle dobi. U ovom istraživanju po prvi put je analizirana imunohistokemijska izraženost BORIS-a i STAM-2 u TGCT-ima, na uzorku od 61 pacijenta. Ova dva proteina sudjeluju u unutarstaničnoj signalizaciji te se smatra da su povezani s aktivacijom protoonkogena. Utvrđena je pozitivna reakcija na BORIS u 100% analiziranih uzoraka, neovisno o histološkoj građi, dok je reakcija na STAM-2 bila slaba ili je nije bilo. Uočena je razlika u izraženosti STAM-2 u čistim seminomima i seminomskoj komponenti MGCT-a u odnosu na ostale komponente MGCT-a. Iako rezultati ovog istraživanja zahtijevaju daljnje potvrde, ukazuju na potencijalno značenje određivanja ekspresije BORIS-a i STAM-2 u TGCT-ima te njihovom eventualnom doprinosu poboljšanju dijagnostike ovih tumora.
Abstract (english)
Testicular germ cell tumours are the most common tumours in young males between puberty and the age of 40. Of all European countries the highest increase of incidence is registered in Republic of Croatia and Republic of Slovenia. The aim of this study was to analyse seminomatous and nonseminomatous tumours of adolescents and younger males. This study was the first to analyse the immunohistochemical expression of BORIS and STAM-2 in TGCTs, in 61 samples. These two proteins play a role in intracellular signalisation and are considered to be involved in activation of protooncogenes. All analysed samples were BORIS-positive, regardless of histological type, whereas the reaction to STAM-2 was weak or absent. There was a difference in the expression of STAM-2 in pure seminomatous tumours and seminomatous component of MGCTs in comparison with other components of MGCTs. Although this study requires further confirmation, it shows the potential significance of determining BORIS and STAM-2 expression and their possible contribution in the improvement of diagnosing TGCTs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:601804
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-12-12 09:42:19