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master's thesis
Akutna bubrežna ozljeda nakon transplantacije jetre
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:858695
Franušić, Lucija
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Franušić, L. (2019). Akutna bubrežna ozljeda nakon transplantacije jetre (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:858695

Franušić, Lucija. "Akutna bubrežna ozljeda nakon transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:858695

Franušić, Lucija. "Akutna bubrežna ozljeda nakon transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:858695

Franušić, L. (2019). 'Akutna bubrežna ozljeda nakon transplantacije jetre', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:858695

Franušić L. Akutna bubrežna ozljeda nakon transplantacije jetre [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:858695

L. Franušić, "Akutna bubrežna ozljeda nakon transplantacije jetre", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:858695

Metadata
TitleAkutna bubrežna ozljeda nakon transplantacije jetre
Title (english)Acute kidney injury after liver transplantation
AuthorLucija Franušić
MentorAnna Mrzljak (mentor)
Committee memberMladen Knotek (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberAnna Mrzljak (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Uvod: Akutna bubrežna ozljeda (AKI eng. acute kidney injury) značajna je komplikacija transplantacije jetre (TJ), a na njezin razvitak utječu brojni faktori. Ciljevi ovog rada bili su odrediti učestalost AKI, istražiti njezinu povezanost s faktorima rizika te istražiti njezin utjecaj na ishod bolesnika nakon transplantacije jetre. ----- Metode: Ova retrospektivno istraživanje uključuje 208 bolesnika koji su podvrgnuti transplantaciji jetre u KB Merkur u razdoblju od listopada 2014. do listopada 2016. godine. Podaci su prikupljeni iz medicinske dokumentacije. AKI je definiran kao porast kreatinina veći od 27 umol/L tijekom prvih 7 dana nakon transplantacije u odnosu na vrijednosti kreatinina prije transplantacije. ----- Rezultati: Vodeća indikacija za TJ bila je alkoholna bolest jetre (51,4%). Većina transplantiranih razvila je AKI unutar prvih sedam dana (56,7%). Bolesnici koji su razvili AKI imali su više vrijednosti BMI, perioperativno primjenjen veći volumen autologne transfuzije i svježe smrznute plazme, više predtransplantacijske vrijednosti kreatinina, natrija kao i prognostičkih zbrojeva MELD i MELD-Na. Mortalitet unutar prvih 30 dana iznosio je 8,6%. Nije uočena povezanost između 30-dnevnog moraliteta i razvoja akutne bubrežne ozljede. ----- Zaključak: Naši podaci pokazuju da je akutnu bubrežnu ozljedu razvije više od polovice bolesnika nakon transplantacije jetre. Češće se pojavljuje u bolesnika sa smanjenom bubrežnom funkcijom i terminalnim stadijem jetrene bolesti prije transplantacije. Akutna bubrežna ozljeda nije povezana s povećanjem mortaliteta unutar 30 dana nakon transplantacije.
Abstract (english)
Background: Acute kidney injury (AKI) is a significant complication after liver transplantation (LT) with multiple risk factors. The aims of this study were to determine incidence of AKI, to identify correlation between AKI and the risk factors and to assess effect of AKI on patient outcome after LT. ----- Methods: This retrospective study included 208 patients transplanted in KB Merkur between October 2014 to October 2016. The data was acquired from medical documents. AKI after LT was defined as an increase in creatinine levels higher than 27 umol/L as compared to creatinine levels before LT. ----- Results: Majority of recipients (51,4%) were transplanted due to alcoholic liver cirrhosis. Cumulative incidence of newly developed AKI was 56,7%. Overall risk of AKI development was associated with higher BMI of recipients, higher doses of autologous transfusion and frozen fresh plasma administered during operation, higher creatinine and sodium levels and MELD/MELD-Na scores before the transplantation. Cumulative incidence of 30- day mortality was 8,6% with higher incidence in patients with arterial hypertension. No correlation was established between 30-day mortality and development of AKI. ----- Conclusion: Results show that more than half of the transplanted patients develop AKI. Development of AKI is more common in patents with decreased kidney function and end stage liver disease. AKI has no correlation to 30- day mortality.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:858695
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-01-29 10:12:33