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master's thesis
Uloga trombina u koagulacijskoj kaskadi
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:198171
Kruško, Damir
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Kruško, D. (2019). Uloga trombina u koagulacijskoj kaskadi (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:198171

Kruško, Damir. "Uloga trombina u koagulacijskoj kaskadi." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:198171

Kruško, Damir. "Uloga trombina u koagulacijskoj kaskadi." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:198171

Kruško, D. (2019). 'Uloga trombina u koagulacijskoj kaskadi', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:198171

Kruško D. Uloga trombina u koagulacijskoj kaskadi [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:198171

D. Kruško, "Uloga trombina u koagulacijskoj kaskadi", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:198171

Metadata
TitleUloga trombina u koagulacijskoj kaskadi
Title (english)The role of thrombin in the coagulation cascade
AuthorDamir Kruško
MentorAna Boban (mentor)
Committee memberRobert Likić (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberAna Boban (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2019-09-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Trombin je enzimski aktivan protein koji ima centralnu ulogu u procesu koagulacijske kaskade. Nastaje aktivacijom protrombina, plazmatskog proteina koji se sintetizira isključivo u jetri. U početku procesa koagulacijske kaskade, male količine trombina aktiviraju faktore V, VIII i XI koji pozitivnom povratnom spregom pospješuju dodatno generiranje trombina. Nagli skok aktiviranog trombina u kasnijoj fazi, pretvaranjem fibrinogena u fibrin posreduje stvaranje fibrinske mrežice i krvnog ugruška. Također, aktiviranjem faktora XIII pojačava čvrstoću fibrinske mrežice te sprječava njenu fibrinolitičku razgradnju plazminom. Vezanjem za trombomodulin, aktivira TAFI te dodatno stabilizira ugrušak. Također, trombin vezanjem za trombomodulin pokreće i sustav prirodnih antikoagulanasa aktivirajući protein C, te time sprječava nekontrolirano generiranje trombina. Stoga se i učinak kako antikoagulantnih tako i prokoagulantnih lijekova postiže pojačavanjem ili inhibicijom djelovanja trombina.
Abstract (english)
Thrombin is an enzyme that has a central role in a process of coagulation cascade. It is produced by the activation of prothrombin, a plasma protein that is synthesized exclusively in the liver. Small amounts of thrombin that are present at the beginning of the coagulation cascade, activate factors V, VIII and XI which promotes further thrombin generation through positive feedback. An abrupt jump in activated thrombin at a later stage, mediates the formation of the fibrin network and blood cloth, by converting fibrinogen to fibrin. Through activation of factor XIII, thrombin enhances the strength of the fibrin network and prevents its fibrinolytic degradation by plasmin. In a complex with thrombomodulin it activates TAFI and further stabilizes the clot. Furthermore, thrombin activates protein C thus activating the system of natural anticoagulant, and therefore preventing the uncontrolled generation of thrombin. Finally, the activity of both anticoagulant and procoagulant drug is achieved by the inhibition or the enhancement of thrombin activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:198171
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-03 16:10:32