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master's thesis
Kontrolirana i nekontrolirana rezistentna hipertenzija
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:086751
Kolić, Marko
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Kolić, M. (2019). Kontrolirana i nekontrolirana rezistentna hipertenzija (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:086751

Kolić, Marko. "Kontrolirana i nekontrolirana rezistentna hipertenzija." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:086751

Kolić, Marko. "Kontrolirana i nekontrolirana rezistentna hipertenzija." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:086751

Kolić, M. (2019). 'Kontrolirana i nekontrolirana rezistentna hipertenzija', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:086751

Kolić M. Kontrolirana i nekontrolirana rezistentna hipertenzija [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:086751

M. Kolić, "Kontrolirana i nekontrolirana rezistentna hipertenzija", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:086751

Metadata
TitleKontrolirana i nekontrolirana rezistentna hipertenzija
Title (english)Controlled and uncontrolled resistant hypertension
AuthorMarko Kolić
MentorIngrid Prkačin (mentor)
Committee memberBojan Jelaković (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberIngrid Prkačin (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Arterijska hipertenzija jedna je od najčešćih kroničnih bolesti populacije te glavni prediktor povišenog kardiovaskularnog rizika. Rezistentna hipertenzija definira se kao stanje u kojem pacijenti unatoč primjeni tri različita antihipertenzivna lijeka od kojih je jedan diuretik ne postižu ciljne vrijednosti krvnog tlaka. Prevalencija rezistentne hipertenzije meĎu hipertenzivnom populacijom iznosi čak 10-15 %. Za dijagnozu rezistentne hipertenzije potrebno je isključiti moguće sekundarne uzroke (opstruktivna „sleep apnea“, primarni hiperaldosteronizam, stenoza renalne arterije) i pseudorezistentnu hipertenziju (nepravilno mjerenje tlaka, efekt bijele kute i nesuradljivost pacijenata prilikom uzimanja antihipertenzivne terapije), te provesti 24-satno mjerenje krvnog tlaka. Rezistentna hipertenzija može se podijeliti na nekontroliranu i kontroliranu rezistentnu hipertenziju s obzirom na vrijednost krvnog tlaka i broj antihipertenziva u terapiji. Obje, i kontrolirana i nekontrolirana rezistentna hipertenzija su heterogeni i kompleksni sindromi koji se razlikuju po patofiziološkom mehanizmu nastanka i kliničkoj prezentaciji. Liječenje uključuje promjene životnih navika i farmakološku terapiju, a kod osoba kod kojih unatoč adekvatnoj terapiji krvni tlak ostaje iznad ciljnih vrijednosti treba razmotriti interventne metode liječenja poput renalne denervacije.
Abstract (english)
Arterial hypertension is one of the most common chronic diseases and main predictor of high cardiovascular risk. Resistant hypertension is defined as a state in which blood pressure remains uncontrolled despite concurrent use of three antihypertensive drugs of which one should be diuretic. The prevalence of resistant hypertension within hypertensive population is even 10-15 %. In diagnostic procedure for resistant hypertension, possible secondary causes (obstructive sleep apnea, primary aldosteronism, renal artery stenosis) and pseudoresistant hypertension (inaccurate measurement of blood pressure, white coat effect, poor adherence to antihypertensive therapy) should be excluded, and also 24-hour ambulatory blood pressure monitoring should be conducted. Resistant hypertension is divided in two major groups according to blood pressure and number of drugs taken: controlled and uncontrolled resistant hypertension. Both controlled an uncontrolled resistant hypertension are heterogenic and complex syndromes which differentiate by pathophysiological mechanism of disease and clinical expression. Treatment strategy includes lifestyle changes and antihypertensive therapy, but if blood pressure remains uncontrolled renal denervation therapy should be considered.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:086751
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-24 14:49:33