Hypertension is the most common chronic disease of the modern age. If we fail to achive the target blood pressure despite the simultaneous full dosage of three antihypertensive drugs, one of which is diuretic, then resistant hypertension is diagnosed. For the diagnosis of resistant hypertension it is important to exclude secondary causes of hypertension and pseudo-resistant hypertension. Continuous measurement of arterial pressure over 24 hours to determine changes in blood pressure during the night is of great importance. It has been determined that changes in blood pressure that occur at night can be used to evaluate cardiovascular risk. Frequent comorbidities of patients with resistant hypertension include diabetes mellitus, hyperlipidemia, obesity. Due to the above mentioned comorbidities, it is necessary to estimate the damage of the target organs. Antihypertensive therapy should be given according to the latest findings and at optimal doses. Central blood pressure is the pressure measured in the area of central arteries including the aorta and common carotid artery. It is measured by invasive and non-invasive methods. It is also an important indicator of future cardiovascular events and damage to target organs in patients with resistant hypertension. The increase in central pulse pressure is a major cause of damage to the cerebral arteries that can lead to cerebrovascular incident. Antihypertensive drugs may have a different effect on lowering central blood pressure compared to decreasing peripheral blood pressure.