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master's thesis
Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:188191
Mazalin, Ante
University of Zagreb
School of Medicine
Department of Infectious Diseases

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Mazalin, A. (2015). Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:188191

Mazalin, Ante. "Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:188191

Mazalin, Ante. "Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:188191

Mazalin, A. (2015). 'Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom', Master's thesis, University of Zagreb, School of Medicine, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:188191

Mazalin A. Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:105:188191

A. Mazalin, "Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:188191

Metadata
TitleEpidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom
Title (english)Epidemiological, clinical and laboratory aspects of lower respiratory system infections caused by respiratory syncytial virus and human metapneumovirus
AuthorAnte Mazalin
MentorGoran Tešović (mentor)
Committee memberDalibor Vukelić (predsjednik povjerenstva)
Committee memberJosip Begovac (član povjerenstva)
Committee memberGoran Tešović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Epidemiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Respiratorni sincicijski virus i humani metapneumovirus važni su uzročnici akutnih infekcija donjeg dišnog sustava u dojenčadi i male djece. RSV primoinfekcija se najčešće javlja u djece između drugog i osmog, a hMPV između šestog i tridesetog mjeseca života. Epidemije RSV-a se javljaju u bianualnim ciklusima, kao veća epidemija zimi koju slijedi manja u proljeće sljedeće godine, a hMPV uglavnom prati ovakav obrazac pojavljivanja. Cilj ovog rada bio je odrediti osobitosti RSV i hMPV infekcija donjih dišnih puteva u hospitalizirane djece u razdoblju od 01. siječnja 2010. do 31. prosinca 2014. godine. U navedenom razdoblju hospitalizirano je ukupno 726 djece s akutnom infekcijom donjeg dišnog sustava u dobi do 5 godina života. RSV i hMPV su u kliničkim uzorcima dokazivani metodom izravne imunofluorescencije. RSV ili hMPV su dokazani u 476 od 726 bolesnika. Od toga je RSV bio uzročnik u 429 (90,13%), a hMPV u 47 (9,87%) slučajeva. Medijan dobi u RSV skupini bio je 3 mjeseca, a u hMPV skupini 6 mjeseci. U 6% bolesnika s RSV-om i 4,2% s hMPV-om bio je prisutan prematuritet ili srčana greška kao rizični čimbenik za težu bolest. Bakterijsku koinfekciju dišnog sustava imalo je 3,5% bolesnika u RSV skupini te 4,2% u hMPV skupini. Mehanički je bilo ventilirano 4,2% RSV pozitivne i 6,4% hMPV pozitivne djece. Gledajući ukupno cijelo razdoblje, hospitalizacije su bile najučestalije u zimskim mjesecima. Vrhunci RSV epidemija javljali su se u zimskim ili proljetnim mjesecima te su pratile bianualni uzorak pojavljivanja. HMPV se također javljao bianualno izmjenjujući se s RSV-om.
Abstract (english)
Respiratory syncytial virus and human metapneumovirus are important causes of acute lower respiratory tract infections in infants and young children. RSV primary infection most commonly occurs in infants aged 2 to 8 months, while hMPV is most common between 6 and 30 months of age. Outbreaks of RSV occur in biennial cycles, as a larger epidemic in winter followed by a smaller epidemic in spring of the next year. HMPV generally follows this pattern of occurrence. The aim of this study was to determine the characteristics of RSV and hMPV lower respiratory tract infections in hospitalized children in period from January 1st 2010 to December 31st 2014. In this period, a total of 726 children under 5 years of age with acute lower respiratory tract infection were hospitalised. Direct immunofluorescence assay (DFA) was used to detect the viruses in clinical samples. RSV and hMPV were detected in 476 out of 726 patients. RSV was causative agent in 429 (90.13%), and hMPV in 47 (9.87%) cases. The median age of RSV patients was 3 months, and hMPV patients 6 months. Prematurity or congenital heart defect as a risk factor for severe disease were present in 6% of patients with RSV and in 4.2% with hMPV infection. Bacterial coinfection was detected in 3.5% of patients in the RSV group and in 4.2% of the hMPV group. Mechanical ventilation was required in 4.2% RSV positive and 6.4% hMPV positive children. Hospitalizations were most common in the winter months. RSV epidemics peaked in winter and spring months and followed biennial pattern of occurrence. HMPV outbreaks also showed biennial pattern and were annualy alternating with RSV peaks.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:188191
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-07-14 08:44:24