prikaz prve stranice dokumenta Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study
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master's thesis
Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:304816
Kirincich, Jason Matthew
University of Zagreb
School of Medicine
Department of Urology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kirincich, J. M. (2019). Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:304816

Kirincich, Jason Matthew. "Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:304816

Kirincich, Jason Matthew. "Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:304816

Kirincich, J. M. (2019). 'Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study', Master's thesis, University of Zagreb, School of Medicine, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:304816

Kirincich JM. Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:304816

J. M. Kirincich, "Multiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:304816

Metadata
TitleMultiple primary malignancies in renal transplant recipients: a single centre retrospective cohort study
Title (croatian)Višestruke primarne malignosti u pacijenata s transplantiranim bubregom: retrospektivna kohortna studija
AuthorJason Matthew Kirincich
MentorNikolina Bašić Jukić (mentor)
Committee memberNikolina Bašić Jukić (predsjednik povjerenstva)
Committee memberŽeljko Kaštelan (član povjerenstva)
Committee memberNikola Đaković (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Urology)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
BACKGROUND/AIMS: Renal transplant recipients are exposed to immunosuppressive treatment which may increase the risk for developing malignancies. Limited data exists concerning the occurrence of multiple primary malignancies (MPM) in renal transplant patients. ----- METHODS: All the patients who received a renal allograft at our institution from 1973 to 2017 were included in this investigation. Data from patients with more MPM were obtained from the charts and medical records. Malignancies were categorized as synchronous if the interval between occurrences was less than or equal to 6 months and metachronous if the interval was more than 6 months. ----- RESULTS: Out of the 1884 patients who received a renal allograft, 164 (8.7%) developed a malignant tumor. Twenty-two patients (13.4%; 6 females, 16 males) developed MPM, 7 synchronous (31.8%) and 15 metachronous types (68.2%). The most common initial primary tumors were skin cancers (8) and kidney cancers (3). Furthermore, skin cancers were the most common second primary malignancies (9). Log-rank analysis revealed significantly better survival in the synchronous group (113.3 months) than in the metachronous group (24.6 months) (p=0.04). ----- CONCLUSION: MPM are more frequent in renal transplant recipients than in the general population. It is associated with a high mortality rate, especially in the metachronous group. An increased awareness and frequent screening tests are necessary when managing this condition.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:105:304816
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteEkvivalent diplomskog rada.
Created on2020-07-15 11:04:58