prikaz prve stranice dokumenta Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage
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Scientific paper - Review paper
Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage
Croatian Medical Journal, 61 (2020), 3; 260-270. https://doi.org/10.3325/cmj.2020.61.260
Bohaček, Ivan; Plečko, Mihovil; Duvančić, Tea; Smoljanović, Tomislav; Vukasović Barišić, Andreja; Delimar, Domagoj

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bohaček, I., Plečko, M., Duvančić, T., Smoljanović, T., Vukasović Barišić, A. & Delimar, D. (2020). Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage. Croatian Medical Journal, 61. (3), 260-270. doi: 10.3325/cmj.2020.61.260

Bohaček, Ivan, et al. "Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage." Croatian Medical Journal, vol. 61, no. 3, 2020, pp. 260-270. https://doi.org/10.3325/cmj.2020.61.260

Bohaček, Ivan, Mihovil Plečko, Tea Duvančić, Tomislav Smoljanović, Andreja Vukasović Barišić and Domagoj Delimar. "Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage." Croatian Medical Journal 61, no. 3 (2020): 260-270. https://doi.org/10.3325/cmj.2020.61.260

Bohaček, I., et al. (2020) 'Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage', Croatian Medical Journal, 61(3), pp. 260-270. doi: 10.3325/cmj.2020.61.260

Bohaček I, Plečko M, Duvančić T, Smoljanović T, Vukasović Barišić A, Delimar D. Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage. Croatian Medical Journal [Internet]. 2020 July 05 [cited 2024 May 02];61(3):260-270. doi: 10.3325/cmj.2020.61.260

I. Bohaček, M. Plečko, T. Duvančić, T. Smoljanović, A. Vukasović Barišić and D. Delimar, "Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage", Croatian Medical Journal, vol. 61, no. 3, pp. 260-270, July 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:221472. [Accessed: 02 May 2024]

Metadata
Title (english)Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage
AuthorIvan Bohaček
AuthorMihovil Plečko
AuthorTea Duvančić
AuthorTomislav Smoljanović
AuthorAndreja Vukasović Barišić
AuthorDomagoj Delimar
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Orthopedics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (english)
Developmental dysplasia of the hip (DDH) represents a morphological abnormality characterized by the incongruity of femoral head and acetabulum. It ranges from mild dysplastic changes to complete dislocation. DDH has been associated with several hereditary and environmental risk factors, which could explain the incidence variability among different countries. Numerous genes may be involved in the disease etiology and progression. However, there are controversies in the literature regarding some of these genes. DDH-induced secondary osteoarthritis (OA) is characterized by changes in the macromolecule content of the cartilage and the expression of cartilage degradation markers. In addition, it exhibits a pattern of specific histological changes, with several reported differences between primary and DDH-induced secondary OA. The articular cartilage of patients with DDH shows specific radiological characteristics, including changes visible already in infancy, but also at pre-arthritic stages, early stages of OA, and in fully developed DDH-induced secondary OA. Although DDH has been extensively researched in different disease stages, the etiology of the disorder still remains uncertain. This review focuses on the current knowledge on the histomorphological status of the cartilage and the genetic background of DDH.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 3, pp. 260-270
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.260
URN:NBNurn:nbn:hr:105:221472
Publication2020-07-05
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358691/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-10-26 13:14:54