prikaz prve stranice dokumenta Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit
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Scientific paper - Original scientific paper
Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit
Croatian Medical Journal, 61 (2020), 5; 429-439. https://doi.org/10.3325/cmj.2020.61.429
Vucelić, Vesna; Klobučar, Iva; Đuras-Cuculić, Branka; Gverić Grginić, Ana; Prohaska-Potočnik, Carmen; Jajić, Ines; Vučičević, Željko; Degoricija, Vesna

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Vucelić, V., Klobučar, I., Đuras Cuculić, B., Gverić Grginić, A., Prohaska Potočnik, C., Jajić, I. ... Degoricija, V. (2020). Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit. Croatian Medical Journal, 61. (5), 429-439. doi: 10.3325/cmj.2020.61.429

Vucelić, Vesna, et al. "Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit." Croatian Medical Journal, vol. 61, no. 5, 2020, pp. 429-439. https://doi.org/10.3325/cmj.2020.61.429

Vucelić, Vesna, Iva Klobučar, Branka Đuras Cuculić, Ana Gverić Grginić, Carmen Prohaska Potočnik, Ines Jajić, Željko Vučičević and Vesna Degoricija. "Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit." Croatian Medical Journal 61, no. 5 (2020): 429-439. https://doi.org/10.3325/cmj.2020.61.429

Vucelić, V., et al. (2020) 'Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit', Croatian Medical Journal, 61(5), pp. 429-439. doi: 10.3325/cmj.2020.61.429

Vucelić V, Klobučar I, Đuras Cuculić B, Gverić Grginić A, Prohaska Potočnik C, Jajić I, and sur.. Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit. Croatian Medical Journal [Internet]. 2020 October 31 [cited 2024 November 26];61(5):429-439. doi: 10.3325/cmj.2020.61.429

V. Vucelić, et al., "Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit", Croatian Medical Journal, vol. 61, no. 5, pp. 429-439, October 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:801790. [Accessed: 26 November 2024]

Metadata
Title (english)Sepsis and septic shock - an observational study of the incidence, management, and mortality predictors in a medical intensive care unit
AuthorVesna Vucelić
AuthorIva Klobučar
AuthorBranka Đuras-Cuculić
AuthorAna Gverić Grginić
AuthorCarmen Prohaska-Potočnik
AuthorInes Jajić
AuthorŽeljko Vučičević
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To prospectively determine the number of patients with sepsis and septic shock in a medical intensive care unit (ICU) using the Sepsis-3 definition; to analyze patients' characteristics, clinical signs, diagnostic test results, treatment and outcomes; and to define independent risk factors for ICU mortality. ----- Methods: This prospective observational study enrolled all patients with the diagnosis of sepsis treated in the medical ICU of "Sestre Milosrdnice" University Hospital Center, Zagreb, between April 2017 and May 2018. ----- Results: Out of 116 patients with sepsis, 54.3% were female. The median age was 73.5 years (IQR 63-82). The leading source of infection was the genitourinary tract (56.9%), followed by the lower respiratory tract (22.4%). A total of 35.3% of the patients experienced septic shock. Total ICU mortality for sepsis was 37.9%: 63.4% in patients with septic shock and 24.0% in patients without shock. Independent risk factors for ICU mortality were reduced mobility level (odds ratio [OR] 11.16, 95% confidence interval [CI] 2.45-50.91), failure to early recognize sepsis in the emergency department (OR 6.59, 95% CI 1.09-39.75), higher Sequential Organ Failure Assessment score at admission (OR 2.37, 95% CI 1.59-3.52), and inappropriate antimicrobial treatment (OR 9.99, 95% CI 2.57-38.87). ----- Conclusion: While reduced mobility level and SOFA score are predetermined characteristics, early recognition of sepsis and the choice of appropriate antimicrobial treatment could be subject to change. Raising awareness of sepsis among emergency department physicians could improve its early recognition and increase the number of timely obtained specimens for microbial cultures.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 5, pp. 429-439
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.429
URN:NBNurn:nbn:hr:105:801790
Publication2020-10-31
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-11-25 09:45:19