prikaz prve stranice dokumenta Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry
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Scientific paper - Original scientific paper
Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry
Croatian Medical Journal, 61 (2020), 5; 440-449. https://doi.org/10.3325/cmj.2020.61.440
Jurin, Ivana; Lucijanić, Marko; Škarić, Zrinka; Hulak Karlak, Vanja; Atić, Armin; Magličić, Ana; Starčević, Boris; Hadžibegović, Irzal

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Jurin, I., Lucijanić, M., Škarić, Z., Hulak Karlak, V., Atić, A., Magličić, A. ... Hadžibegović, I. (2020). Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry. Croatian Medical Journal, 61. (5), 440-449. doi: 10.3325/cmj.2020.61.440

Jurin, Ivana, et al. "Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry." Croatian Medical Journal, vol. 61, no. 5, 2020, pp. 440-449. https://doi.org/10.3325/cmj.2020.61.440

Jurin, Ivana, Marko Lucijanić, Zrinka Škarić, Vanja Hulak Karlak, Armin Atić, Ana Magličić, Boris Starčević and Irzal Hadžibegović. "Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry." Croatian Medical Journal 61, no. 5 (2020): 440-449. https://doi.org/10.3325/cmj.2020.61.440

Jurin, I., et al. (2020) 'Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry', Croatian Medical Journal, 61(5), pp. 440-449. doi: 10.3325/cmj.2020.61.440

Jurin I, Lucijanić M, Škarić Z, Hulak Karlak V, Atić A, Magličić A, and sur.. Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry. Croatian Medical Journal [Internet]. 2020 October 31 [cited 2024 November 08];61(5):440-449. doi: 10.3325/cmj.2020.61.440

I. Jurin, et al., "Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry", Croatian Medical Journal, vol. 61, no. 5, pp. 440-449, October 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:219604. [Accessed: 08 November 2024]

Metadata
Title (english)Patterns of anticoagulation therapy in atrial fibrillation: results from a large real-life single-center registry
AuthorIvana Jurin
AuthorMarko Lucijanić
AuthorZrinka Škarić
AuthorVanja Hulak Karlak
AuthorArmin Atić
AuthorAna Magličić
AuthorBoris Starčević
AuthorIrzal Hadžibegović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To investigate the differences in the characteristics and clinical outcomes of recently diagnosed patients with atrial fibrillation (AF) receiving different types of anticoagulants in a real-life setting. ----- Methods: We retrospectively analyzed the charts of 1000 consecutive patients with non-valvular AF diagnosed at our institution or referred it to from 2013 to 2018. ----- Results: Over the observed period, the frequency of direct oral anticoagulation (DOAC) therapy use significantly increased (P = 0.002). Patients receiving warfarin had more unfavorable thromboembolic and bleeding risk factors than patients receiving DOAC. Predetermined stroke and major bleeding risks were similarly distributed among the dabigatran, rivaroxaban, and apixaban groups. Patients receiving warfarin had shorter time-to-major bleeding (TTB), time to thrombosis (TTT), and overall survival (OS) than patients receiving DOACs. After adjustment for factors unbalanced at baseline, the warfarin group showed significantly shorter OS (hazard ratio 2.27, 95% confidence interval 1.44-3.57, P<0.001], while TTB and TTT did not significantly differ between the groups. Only 37% of patients on warfarin had optimal dosing control, and they did not differ significantly in TTB, TTT, and OS from patients on DOACs. ----- Conclusion: Warfarin and DOACs are administered to different target populations, possibly due to socio-economic reasons. Patients receiving warfarin rarely obtain optimal dosing control, and experience significantly shorter survival compared with patients receiving DOACs.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 5, pp. 440-449
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.440
URN:NBNurn:nbn:hr:105:219604
Publication2020-10-31
Document URLhttp://www.cmj.hr/2020/61/5/33150762.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-11-25 12:51:39