Title (croatian) Genitalne HPV infekcije u trudnoći Title (english) Genital HPV infections in pregnancy Author Karla Kovačević Author Mihael Skerlev Author Hrvoje Vrčić Author Petra Kovačević Author Suzana Ljubojević Hadžavdić Author's institution University of Zagreb Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract (croatian) Humani papiloma virusi (HPV) su mali, epitelotropni DNK virusi. Dosadašnji podatci ukazuju na postojanje
više od dvjesto genotipova virusa, od kojih oko četrdeset uzrokuje infekcije genitalnog područja. S obzirom
na onkogeni potencijal, razlikujemo genotipove visokog (HPV 16, HPV 18, itd.) i genotipove niskog rizika (HPV 6,
HPV 11, itd.). Genitalni HPV najčešće se prenosi kontaktom s inficiranom kožom ili sluznicom. Ostali načini prijenosa
uključuju neizravni kontakt s kontaminiranim predmetima te autoinokulaciju. HPV uzrokuje različite
promjene
genitalne regije poput kondiloma, intraepitelnih neoplazija i invazivnih karcinoma cerviksa, vulve,
penisa ili anusa. Također, HPV može prouzročiti lezije u područjima izvan genitalne regije kao što su usna šupljina,
ždrijelo, grlo i jednjak. Ne postoji suglasnost vezana uz prevalenciju HPV-a tijekom trudnoće, pa ona varira u
različitim zemljama između 5,5% i 65%. Vertikalni prijenos HPV-a označava mogućnost prijenosa HPV-a s majke
na dijete tijekom trudnoće. Do perikonceptualnog prijenosa HPV DNA dolazi u vrijeme fertilizacije, dok se antenatalni
prijenos događa isključivo za vrijeme trudnoće. No, većina HPV infekcija novorođenčadi nastaje perinatalnim
prijenosom tijekom porođaja. Incidencija anogenitalnih kondiloma u trudnoći iznosi između 11,6% i 28,2%. Oni
predstavljaju rizik od kontaminacije novorođenčeta HPV-om tijekom porođaja. Porastom učestalosti pojavljivanja
anogenitalnih kondiloma u odraslih uočen je i usporedni porast incidencije anogenitalnih kondiloma u djece. HPV
u djece može uzrokovati i rekurentnu respiratornu papilomatozu koju karakterizira nastajanje multiplih papiloma
glasnica. Rijetko dolazi do totalne opstrukcije dišnog puta ili progresije u karcinom.
Abstract (english) Human papilloma viruses (HPV) are small, epitheliotropic DNA viruses. More than two hundred
different HPV genotypes are known today, of which around forty types cause genital infection. According to their
oncogenic potential the viruses are divided in high-risk HPV genotypes (HPV 16, HPV 18, etc.) and low-risk genotypes
(HPV 6, HPV 11, etc.). Genital HPV is most frequently transmitted through contact with infected skin or
mucous membranes. Other routes of transmission are via contaminated fomites and autoinoculation. HPV causes
genital warts, intraepithelial neoplasia and invasive carcinoma of cervix, vulva, penis or anus.Also, HPV can cause
lesions in non-genital areas such as oral cavity, pharynx, throat and esophagus. There is no consensus regarding
the prevalence of HPV during pregnancy, so it varies in different countries between 5.5 % and 65 %. The otential
route of HPV transmission from mother to child during pregnancy is known as vertical transmission. Periconceptual
transmission of HPV DNA occurs during fertilization, while prenatal transmission happens only during pregnancy.
Most infant HPV infections occur via perinatal transmission during delivery. The incidence of anogenital
warts in pregnancy is between 11.6 % and 28.2 %. Anogenital warts increase the risk of infant HPV contamination
during delivery. As the incidence of anogenital warts increased in adults, increased incidence was also
reported in children. HPV can cause recurrent respiratory papillomatosis in children, a disease characterized with
laryngeal papillomatosis. In rare cases, total obstruction of airway or progression in carcinoma can occur.
Keywords (croatian)
INFEKCIJE HUMANIM PAPILOMA VIRUSOM – patologija, prijenos, virologija
KOMPLIKACIJE INFEKCIJA U TRUDNOĆI – patologija, virologija
INFEKCIJE GENITALNOG TRAKTA – patologija, virologija
SPOLNO PRENOSIVE BOLESTI – patologija, prijenos, virologija
VERTIKALNI PRIJENOS INFEKCIJE
INFEKCIJE ONKOGENIM VIRUSOM – prijenos, virologija
ŠILJASTI KONDILOMI – liječenje, virologija
INFEKCIJE DIŠNOG SUSTAVA – dijagnoza, liječenje, virologija
NOVOROĐENČE
Keywords (english)
PAPILLOMAVIRUS INFECTIONS – pathology, transmission, virology
PREGNANCY COMPLICATIONS, INFECTIOUS – pathology, virology
REPRODUCTIVE TRACT INFECTIONS – pathology, virology
SEXUALLY TRANSMITTED DISEASES – pathology, transmission, virology
INFECTIOUS DISEASE TRANSMISSION, VERTICAL
TUMOR VIRUS INFECTIONS – transmission, virology
CONDYLOMATA ACUMINATA – therapy, virology
RESPIRATORY TRACT INFECTIONS – diagnosis, therapy, virology
INFANT
NEWBORN
Language croatian Publication type Scientific paper - Review paper Publication status Published Peer review Peer review Publication version Published version Journal title Liječnički vjesnik Numbering vol. 142, no. 7-8, pp. 244-250 p-ISSN 0024-3477 e-ISSN 1849-2177 DOI https://doi.org/10.26800/LV-142-7-8-40 URN:NBN urn:nbn:hr:105:437693 Publication 2020 Document URL https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=353590 Type of resource Text Access conditions Open access Terms of use Created on 2020-11-26 08:36:15
