Oral hormonal contraception (OHC) has been in use for over 50 years and today it is considered the most reliable reversible contraceptive method. Since the start of its application approximately 300 million women have been using the method and today it is estimated that between 70 and 80 million women are using this method. Oral hormonal contraception is considered the most tested compound in the history of medicine because of the long period of usage and the large number of women using it. OHC has both contraceptive and non-contraceptive effects. The non-contraceptive effects are exactly what acts protectively on women's health and adds to the benefits of using OHC. Many studies have confirmed that OHC compounds decrease the risk of extrauterine pregnancies, functional ovary cysts, benign breast diseases, inflammatory pelvic diseases, osteoporosis and rheumatoid arthritis. They also reduce the occurrence risk of very malignant diseases such as ovarian and endometrial cancer and colon cancer. OHC compounds are also applied for menstrual cycle regulation and are also used to treat endometriosis, myomas and hypergonadism as well as polycystic ovarian syndrome, the most common endocrinopathy in women today. Even though it is often misinterpreted in the public, the advantages of using OHC surpass their deficiencies, so today OHC compounds are considered as a guardian of female reproductive health.