prikaz prve stranice dokumenta Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
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Scientific paper - Original scientific paper
Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
Radiology and Oncology, 53 (2019), 4; 488-496. https://doi.org/10.2478/raon-2019-0055
Prpić, Marin; Kruljac, Ivan; Kust, Davor; Suton, Petar; Purgar, Neva; Biloš, Lora Kirigin; Gregov, Marin; Mrcela, Iva; Franceschi, Maja; Đakovic, Nikola; Frobe, Ana

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Prpić, M., Kruljac, I., Kust, D., Suton, P., Purgar, N., Biloš, L. K. ... Frobe, A. (2019). Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients. Radiology and Oncology, 53. (4), 488-496. doi: 10.2478/raon-2019-0055

Prpić, Marin, et al. "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients." Radiology and Oncology, vol. 53, no. 4, 2019, pp. 488-496. https://doi.org/10.2478/raon-2019-0055

Prpić, Marin, Ivan Kruljac, Davor Kust, Petar Suton, Neva Purgar, Lora Kirigin Biloš, Marin Gregov, et al. "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients." Radiology and Oncology 53, no. 4 (2019): 488-496. https://doi.org/10.2478/raon-2019-0055

Prpić, M., et al. (2019) 'Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients', Radiology and Oncology, 53(4), pp. 488-496. doi: 10.2478/raon-2019-0055

Prpić M, Kruljac I, Kust D, Suton P, Purgar N, Biloš LK, and sur.. Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients. Radiology and Oncology [Internet]. 2019 November 20 [cited 2024 April 24];53(4):488-496. doi: 10.2478/raon-2019-0055

M. Prpić, et al., "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients", Radiology and Oncology, vol. 53, no. 4, pp. 488-496, November 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:982480. [Accessed: 24 April 2024]

Metadata
Title (english)Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
AuthorMarin Prpić
AuthorIvan Kruljac
AuthorDavor Kust
AuthorPetar Suton
AuthorNeva Purgar
AuthorLora Kirigin Biloš
AuthorMarin Gregov
AuthorIva Mrcela
AuthorMaja Franceschi
AuthorNikola Đakovic
AuthorAna Frobe
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Clinical Oncology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Background The aim of this study was to determine the possible predictive value of various dosimetric parameters on the development of hypothyroidism (HT) in patients with head and neck squamous cell carcinoma (HNSCC) treated with (chemo)radiotherapy. ----- Patients and methods This study included 156 patients with HNSCC who were treated with (chemo)radiotherapy in a primary or postoperative setting between August 2012 and September 2017. Dose-volume parameters as well as V10 toV70, D02 to D98, and the VS10 to VS70 were evaluated. The patients’ hormone status was regularly assessed during follow-up. A nomogram (score) was constructed, and the Kaplan-Maier curves and Log-Rank test were used to demonstrate the difference in incidence of HT between cut-off values of specific variables. ----- Results After a median follow-up of 23.0 (12.0–38.5) months, 70 (44.9%) patients developed HT. In univariate analysis, VS65, Dmin, V50, and total thyroid volume (TTV) had the highest accuracy in predicting HT. In a multivariate model, HT was associated with lower TTV (OR 0.31, 95% CI 0.11–0.87, P = 0.026) and Dmin (OR 9.83, 95% CI 1.89–108.08, P = 0.042). Hypothyroidism risk score (HRS) was constructed as a regression equation and comprised TTV and Dmin. HRS had an AUC of 0.709 (95% CI 0.627–0.791). HT occurred in 13 (20.0%) patients with a score < 7.1 and in 57 (62.6%) patients with a score > 7.1. ----- Conclusions The dose volume parameters VS65, Dmin, V50, and TTV had the highest accuracy in predicting HT. The HRS may be a useful tool in detecting patients with high risk for radiation-induced hypothyroidism.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleRadiology and Oncology
Numberingvol. 53, no. 4, pp. 488-496
e-ISSN1581-3207
DOIhttps://doi.org/10.2478/raon-2019-0055
URN:NBNurn:nbn:hr:105:982480
Publication2019-11-20
Document URLhttps://content.sciendo.com/doi/10.2478/raon-2019-0055
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) icon
Created on2020-12-08 12:48:22