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Scientific paper - Original scientific paper
Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?
Acta Neurologica Belgica, 120 (2020), 3; 581-587. https://doi.org/10.1007/s13760-018-1051-4
Habek, Mario; Mutak, Tomislav; Nevajdić, Bojana; Pucić, Dunja; Crnošija, Luka; Krbot Skorić, Magdalena

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Habek, M., Mutak, T., Nevajdić, B., Pucić, D., Crnošija, L. & Krbot Skorić, M. (2020). Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?. Acta Neurologica Belgica, 120. (3), 581-587. doi: 10.1007/s13760-018-1051-4

Habek, Mario, et al. "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?." Acta Neurologica Belgica, vol. 120, no. 3, 2020, pp. 581-587. https://doi.org/10.1007/s13760-018-1051-4

Habek, Mario, Tomislav Mutak, Bojana Nevajdić, Dunja Pucić, Luka Crnošija and Magdalena Krbot Skorić. "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?." Acta Neurologica Belgica 120, no. 3 (2020): 581-587. https://doi.org/10.1007/s13760-018-1051-4

Habek, M., et al. (2020) 'Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?', Acta Neurologica Belgica, 120(3), pp. 581-587. doi: 10.1007/s13760-018-1051-4

Habek M, Mutak T, Nevajdić B, Pucić D, Crnošija L, Krbot Skorić M. Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?. Acta Neurologica Belgica [Internet]. 2020 June [cited 2024 November 26];120(3):581-587. doi: 10.1007/s13760-018-1051-4

M. Habek, T. Mutak, B. Nevajdić, D. Pucić, L. Crnošija and M. Krbot Skorić, "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?", Acta Neurologica Belgica, vol. 120, no. 3, pp. 581-587, June 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:377935. [Accessed: 26 November 2024]

Metadata
Title (english)Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?
AuthorMario Habek
AuthorTomislav Mutak
AuthorBojana Nevajdić
AuthorDunja Pucić
AuthorLuka Crnošija
AuthorMagdalena Krbot Skorić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
The aim of the study is to investigate differences in non-standard adrenergic baroreflex sensitivity (BRS) indices in patients with different phenotypes of multiple sclerosis (pwMS) and healthy controls (HC). Retrospective analysis of types of systolic blood pressure (BP) curves during Valsalva maneuver (VM) [balanced (BAR), augmented (AAR) and suppressed (SAR) autonomic responses] and adrenergic baroreflex sensitivity (BRSa) measured with BRSa1, α-BRSa and β-BRSa in patients with clinically isolated syndrome (CIS), relapsing remitting multiple sclerosis (RRMS), progressive multiple sclerosis (PMS) and HC. We also investigated correlations between BRSa1, α-BRSa, β-BRSa and resting catecholamine levels. pwMS had higher α-BRSa compared to HC (p = 0.02). There was no difference in BRSa1, s and β-BRSa between patients with CIS, RRMS and PMS. There was no association between pwMS and HC, and the type of sBP curve [χ2 = 4.332, p = 0.114]. pwMS and BAR or AAR had higher supine systolic and diastolic BP compared to pwMS and SAR. There was a significant correlation between α-BRSa and upright systolic BP (rp =0.194, p = 0.017), α-BRSa and norepinephrine (rs =0.228, p = 0.021), and BRSa1 and epinephrine (rs = 0.226, p = 0.040). pwMS and HC exhibit different alpha-adrenergic response to Valsalva maneuver. These results may explain the connection between MS and increased cardiovascular risk.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleActa Neurologica Belgica
Numberingvol. 120, no. 3, pp. 581-587
p-ISSN0300-9009
e-ISSN2240-2993
DOIhttps://doi.org/10.1007/s13760-018-1051-4
URN:NBNurn:nbn:hr:105:377935
Publication2020-06
Document URLhttp://link.springer.com/10.1007/s13760-018-1051-4
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-06-30
Terms of useLicence In copyright icon
Created on2021-01-14 09:36:00