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Scientific paper - Original scientific paper
Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study
American Journal of Otolaryngology, 41 (2020), 3; 102416. https://doi.org/10.1016/j.amjoto.2020.102416
Košec, Andro; Hergešić, Filip; Matovinović, Filip; Rašić, Ivan; Vagić, Davor; Bedeković, Vladimir

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Košec, A., Hergešić, F., Matovinović, F., Rašić, I., Vagić, D. & Bedeković, V. (2020). Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study. American Journal of Otolaryngology, 41. (3). doi: 10.1016/j.amjoto.2020.102416

Košec, Andro, et al. "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study." American Journal of Otolaryngology, vol. 41, no. 3, 2020. https://doi.org/10.1016/j.amjoto.2020.102416

Košec, Andro, Filip Hergešić, Filip Matovinović, Ivan Rašić, Davor Vagić and Vladimir Bedeković. "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study." American Journal of Otolaryngology 41, no. 3 (2020). https://doi.org/10.1016/j.amjoto.2020.102416

Košec, A., et al. (2020) 'Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study', American Journal of Otolaryngology, 41(3). doi: 10.1016/j.amjoto.2020.102416

Košec A, Hergešić F, Matovinović F, Rašić I, Vagić D, Bedeković V. Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study. American Journal of Otolaryngology [Internet]. 2020 June [cited 2024 November 23];41(3). doi: 10.1016/j.amjoto.2020.102416

A. Košec, F. Hergešić, F. Matovinović, I. Rašić, D. Vagić and V. Bedeković, "Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study", American Journal of Otolaryngology, vol. 41, no. 3, June 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:502921. [Accessed: 23 November 2024]

Metadata
Title (english)Identifying early postoperative serum parathyroid hormone levels as predictors of hypocalcaemia after total thyroidectomy: A prospective non-randomized study
AuthorAndro Košec
AuthorFilip Hergešić
AuthorFilip Matovinović
AuthorIvan Rašić
AuthorDavor Vagić
AuthorVladimir Bedeković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Othorhinolaryngology and Head and Neck Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
Objective: There is no clear cut-off value of serum parathyroid hormone (PTH) or calcium in which patients are at risk for hypocalcemia after total thyroidectomy. We evaluated the usefulness of serum calcium and PTH concentration measurements after total thyroidectomy in predicting late-occurring hypocalcemia. ----- Design: A prospective, single-center, non-randomized longitudinal cohort study of 143 patients undergoing thyroidectomy between August 2019 and December 2019 with serum calcium and PTH levels sampled 1 h after surgery and on the first and fifth postoperative day. Hypocalcemia was defined as serum calcium levels < 2.14 mmol/L regardless of clinical symptoms. Normal PTH range was 1.6-6.9 pmol/L. ----- Measurements: The primary outcome measure was presence of hypocalcemia on the first and fifth postoperative day, analyzed by a logistic regression model. The PTH cut-off value for prediction of hypocalcemia was identified using a ROC curve comparing all three time points using the Youden J index. ----- Results: Out of 143 patients, 52 (36.4%) had hypocalcemia on the fifth postoperative day. Advanced age, concomitant neck dissection and serum PTH levels < 2.9 pmol/L 1 h after surgery and on the first postoperative surgery day were associated with a high risk of hypocalcemia on the first and fifth postoperative day and need for higher doses of calcium supplements (P < 0.0001, AUC 0.748, 95% CI 0.669-0.817, with 76.92% sensitivity and 71.43% specificity). ----- Conclusion: Serum PTH level measured immediately postoperatively and on the first postoperative day is a reliable predictor of postoperative hypocalcemia with important clinical implications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleAmerican Journal of Otolaryngology
Numberingvol. 41, no. 3, 102416
p-ISSN0196-0709
e-ISSN1532-818X
DOIhttps://doi.org/10.1016/j.amjoto.2020.102416
URN:NBNurn:nbn:hr:105:502921
Publication2020-06
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0196070920300879
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-07-01
Terms of useLicence In copyright icon
Created on2021-01-21 12:52:16