prikaz prve stranice dokumenta Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive
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Scientific paper - Original scientific paper
Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive
Microbial Drug Resistance, 25 (2019), 5; 696-702. https://doi.org/10.1089/mdr.2018.0309
Tomić Paradžik, Maja; Drenjančević, Domagoj; Presečki-Stanko, Aleksandra; Kopić, Jasminka; Talapko, Jasminka; Zarfel, Gernot; Bedenić, Branka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Tomić Paradžik, M., Drenjančević, D., Presečki Stanko, A., Kopić, J., Talapko, J., Zarfel, G. & Bedenić, B. (2019). Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive. Microbial Drug Resistance, 25. (5), 696-702. doi: 10.1089/mdr.2018.0309

Tomić Paradžik, Maja, et al. "Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive." Microbial Drug Resistance, vol. 25, no. 5, 2019, pp. 696-702. https://doi.org/10.1089/mdr.2018.0309

Tomić Paradžik, Maja, Domagoj Drenjančević, Aleksandra Presečki Stanko, Jasminka Kopić, Jasminka Talapko, Gernot Zarfel and Branka Bedenić. "Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive." Microbial Drug Resistance 25, no. 5 (2019): 696-702. https://doi.org/10.1089/mdr.2018.0309

Tomić Paradžik, M., et al. (2019) 'Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive', Microbial Drug Resistance, 25(5), pp. 696-702. doi: 10.1089/mdr.2018.0309

Tomić Paradžik M, Drenjančević D, Presečki Stanko A, Kopić J, Talapko J, Zarfel G, and sur.. Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive. Microbial Drug Resistance [Internet]. 2019 June [cited 2024 November 22];25(5):696-702. doi: 10.1089/mdr.2018.0309

M. Tomić Paradžik, et al., "Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive", Microbial Drug Resistance, vol. 25, no. 5, pp. 696-702, June 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:852706. [Accessed: 22 November 2024]

Metadata
Title (english)Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive
AuthorMaja Tomić Paradžik
AuthorDomagoj Drenjančević
AuthorAleksandra Presečki-Stanko
AuthorJasminka Kopić
AuthorJasminka Talapko
AuthorGernot Zarfel
AuthorBranka Bedenić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
The purpose of this study was to report the identification OXA-48 carbapenemase in seven extended-spectrum β-lactamase (ESBL)-positive Escherichia coli clinical isolates, fully susceptible to all carbapenems by disk diffusion and E-test methods, but with borderline minimal inhibitory concentration (MIC) values of ertapenem. This report points to the necessity for determination of carbapenem MICs in ESBL-positive E. coli isolates and additional phenotypic testing for carbapenemases in all isolates with borderline ertapenem MIC defined by EUCAST. The isolates showed a high level of resistance to expanded-spectrum cephalosporins because of the production of an additional ESBL belonging to CTX-M family. All isolates and their respective tranconjugants were found to possess L plasmid. Pulsed-field gel electrophoresis analysis revealed two clusters containing highly related isolates. The global spread of multidrug-resistant E. coli should be monitored closely because of the ability of isolates to rapidly obtain additional antibiotic resistance traits such as plasmid-mediated OXA-48 genes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMicrobial Drug Resistance
Numberingvol. 25, no. 5, pp. 696-702
p-ISSN1076-6294
e-ISSN1931-8448
DOIhttps://doi.org/10.1089/mdr.2018.0309
URN:NBNurn:nbn:hr:105:852706
Publication2019-06
Document URLhttps://www.liebertpub.com/doi/10.1089/mdr.2018.0309
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-02-03 10:04:39