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master's thesis
Utjecaj okoliša na epigenom u trudnoći
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:163519
Antolović, Antonija
University of Zagreb
School of Medicine
Department of Medical Biology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Antolović, A. (2019). Utjecaj okoliša na epigenom u trudnoći (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:163519

Antolović, Antonija. "Utjecaj okoliša na epigenom u trudnoći." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:163519

Antolović, Antonija. "Utjecaj okoliša na epigenom u trudnoći." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:163519

Antolović, A. (2019). 'Utjecaj okoliša na epigenom u trudnoći', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:163519

Antolović A. Utjecaj okoliša na epigenom u trudnoći [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:163519

A. Antolović, "Utjecaj okoliša na epigenom u trudnoći", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:163519

Metadata
TitleUtjecaj okoliša na epigenom u trudnoći
Title (english)Environmental effects on the epigenome in pregnancy
AuthorAntonija Antolović
MentorAna Katušić Bojanac (mentor)
Committee memberFloriana Jakuš (predsjednik povjerenstva)
Committee memberLjiljana Šerman (član povjerenstva)
Committee memberAna Katušić Bojanac (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Fetalno razdoblje ključni je period za oblikovanje obrazaca DNA metilacije i genske ekspresije. Ono predstavlja kritičnu točku u razvoju pošto epigenetske modifikacije nastale tada mogu perzistirati kasnije u životu i predstavljati rizični faktor za razvoj bolesti kasnije u životu. Najčešća epigenetska modifikacija je metilacija DNA, a slijede ju modifikacija histona te posredovanje nekodirajućih RNA. Te promjene igraju ključnu ulogu u regulaciji genskih funkcija, ali ne mijenjaju DNA sekvencu i nastaju pod utjecajem okolišnih čimbenika kojima je izložena majka te njenih navika u trudnoći (na primjer konzumacija alkohola, izloženost duhanskom dimu, uzimanje lijekova tokom trudnoće itd.). Iako u trudnoći dolazi do globalnog brisanja metilacijskih obrazaca (demetilacije) u spolnim stanicama, znamo da je moguće nasljeđivanje epigenetskih modifikacija. U potomaka F1 i F2 generacije radi se zapravo o posrednoj izloženosti okolišnim čimbenicima, a u ovom preglednom radu razmatra se mogućnost transgeneracijskog nasljeđivanja u pravom smislu, tj. mogućnost da potomak koji nije izložen nekom okolišnom čimbeniku naslijedi epigenetske promjene koje nastaju u jedinki izloženih istome.
Abstract (english)
DNA methylation patterns and gene expression are formed during fetal development therefore making this period the crucial point for epigenetic modifications to occur and persist through life and later on lead to development of disease. Epigenetic modifications are enzyme-mediated chemical modifications of DNA which play key roles in regulating gene functions without altering the primary DNA sequence. The most common one is DNA methylation followed by histone modification and non-coding RNAs which occur whilst the mother being exposed to environmental factors and due to her habits during pregnancy (for example alcohol abuse, exposure to tobacco smoke, taking medications during pregnancy, etc). Although global demethylation in leads to loss of methylation patterns, inheritance of epigenetic modifications remains possible due to indirect exposure to environmental factors of the F1 and F2 generation. The following thesis contemplates the possibility of transgenerational inheritance of epigenetic changes from indirectly exposed to the non-exposed offspring.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:163519
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-02-25 10:19:12