prikaz prve stranice dokumenta FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
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Scientific paper - Original scientific paper
FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
Croatian Medical Journal, 61 (2020), 6; 547-555. https://doi.org/10.3325/cmj.2020.61.547
Artuković, Marinko; Ikić Matijašević, Marina; Markotić, Antonio; Šućur, Alan; Grcevic, Danka; Kovačić, Nataša; Flegar, Darja; Stipić Marković, Asja; Šisl, Dino; Artuković, Irena; Kelava, Tomislav

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Artuković, M., Ikić Matijašević, M., Markotić, A., Šućur, A., Grcevic, D., Kovačić, N. ... Kelava, T. (2020). FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population. Croatian Medical Journal, 61. (6), 547-555. doi: 10.3325/cmj.2020.61.547

Artuković, Marinko, et al. "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population." Croatian Medical Journal, vol. 61, no. 6, 2020, pp. 547-555. https://doi.org/10.3325/cmj.2020.61.547

Artuković, Marinko, Marina Ikić Matijašević, Antonio Markotić, Alan Šućur, Danka Grcevic, Nataša Kovačić, Darja Flegar, et al. "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population." Croatian Medical Journal 61, no. 6 (2020): 547-555. https://doi.org/10.3325/cmj.2020.61.547

Artuković, M., et al. (2020) 'FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population', Croatian Medical Journal, 61(6), pp. 547-555. doi: 10.3325/cmj.2020.61.547

Artuković M, Ikić Matijašević M, Markotić A, Šućur A, Grcevic D, Kovačić N, and sur.. FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population. Croatian Medical Journal [Internet]. 2020 December 31 [cited 2024 May 19];61(6):547-555. doi: 10.3325/cmj.2020.61.547

M. Artuković, et al., "FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population", Croatian Medical Journal, vol. 61, no. 6, pp. 547-555, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:713088. [Accessed: 19 May 2024]

Metadata
Title (english)FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
AuthorMarinko Artuković
AuthorMarina Ikić Matijašević
AuthorAntonio Markotić
AuthorAlan Šućur
AuthorDanka Grcevic
AuthorNataša Kovačić
AuthorDarja Flegar
AuthorAsja Stipić Marković
AuthorDino Šisl
AuthorIrena Artuković
AuthorTomislav Kelava
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Physiology and Immunology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Aim: To investigate the association of FasL gene polymorphism (rs763110) with rheumatoid arthritis occurrence, disease activity, and tumor necrosis factor-α (TNF-α) plasma concentration in Croatian patients, and to conduct an updated meta-analysis. ----- Methods: This cross-sectional study enrolled 81 patients with rheumatoid arthritis and 94 control patients. After the assessment of the Disease Activity Score (DAS)-28, blood was taken for analysis. DNA was isolated from the whole blood to determine FasL polymorphism (rs763110) by polymerase chain reaction. Protein levels of TNF-α were determined with ELISA. After a detailed literature search, we conducted an updated meta-analysis using the Review Manager 5 software. ----- Results: Rheumatoid arthritis patients had significantly higher TNF-α concentration in plasma (1.65 [1.2-2.42] pg/mL) than controls (0.99 [0.77-1.35] pg/mL, P<0.001). The FasL rs763110 polymorphism was not associated with rheumatoid arthritis occurrence in either codominant, dominant, recessive, overdominant, or log additive model. Furthermore, the rs763110 genotype was not associated with DAS 28 score or TNF-α concentration. After we added our results to an updated meta-analysis, the significant association previously reported for Western Eurasians was abolished. ----- Conclusion: Our data suggest that the association between FasL rs763110 polymorphism and RA susceptibility in Western Eurasians observed in previous studies might be overestimated and should be limited to the population of Southwestern Asia until further investigations are performed.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 6, pp. 547-555
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.547
URN:NBNurn:nbn:hr:105:713088
Publication2020-12-31
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821374/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-02-25 10:34:46