prikaz prve stranice dokumenta Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)
  Download
PDF 1.25 MB
Scientific paper - Original scientific paper
Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)
Genes, 10 (2019), 10; 783. https://doi.org/10.3390/genes10100783
Ozretić, Petar; da Silva Filho, Miguel Inacio; Catalano, Calogerina; Sokolović, Irena; Vukić-Dugac, Andrea; Šutić, Maja; Kurtović, Matea; Bubanović, Gordana; Popović-Grle, Sanja; Skrinjarić-Cincar, Sanda; Vugrek, Oliver; Jukić, Irena; Rumora, Lada; Bosnar, Martina; Samaržija, Miroslav; Bals, Robert; Jakopović, Marko; Försti, Astra; Knežević, Jelena More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Ozretić, P., da Silva Filho, M. I., Catalano, C., Sokolović, I., Vukić Dugac, A., Šutić, M. ... Knežević, J. (2019). Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Genes, 10. (10). doi: 10.3390/genes10100783

Ozretić, Petar, et al. "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)." Genes, vol. 10, no. 10, 2019. https://doi.org/10.3390/genes10100783

Ozretić, Petar, Miguel Inacio da Silva Filho, Calogerina Catalano, Irena Sokolović, Andrea Vukić Dugac, Maja Šutić, Matea Kurtović, et al. "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)." Genes 10, no. 10 (2019). https://doi.org/10.3390/genes10100783

Ozretić, P., et al. (2019) 'Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)', Genes, 10(10). doi: 10.3390/genes10100783

Ozretić P, da Silva Filho MI, Catalano C, Sokolović I, Vukić Dugac A, Šutić M, and sur.. Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Genes [Internet]. 2019 October 09 [cited 2024 November 25];10(10). doi: 10.3390/genes10100783

P. Ozretić, et al., "Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)", Genes, vol. 10, no. 10, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:383052. [Accessed: 25 November 2024]

Metadata
Title (english)Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)
AuthorPetar Ozretić
AuthorMiguel Inacio da Silva Filho
AuthorCalogerina Catalano
AuthorIrena Sokolović
AuthorAndrea Vukić-Dugac
AuthorMaja Šutić
AuthorMatea Kurtović
AuthorGordana Bubanović
MBZ: 319765
AuthorSanja Popović-Grle
AuthorSanda Skrinjarić-Cincar
AuthorOliver Vugrek
AuthorIrena Jukić
AuthorLada Rumora
AuthorMartina Bosnar
AuthorMiroslav Samaržija
AuthorRobert Bals
AuthorMarko Jakopović
AuthorAstra Försti
AuthorJelena Knežević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by a progressive decline in lung function due to airflow limitation, mainly related to IL-1β-induced inflammation. We have hypothesized that single nucleotide polymorphisms (SNPs) in NLRP genes, coding for key regulators of IL-1β, are associated with pathogenesis and clinical phenotypes of COPD. We recruited 704 COPD individuals and 1238 healthy controls for this study. Twenty non-synonymous SNPs in 10 different NLRP genes were genotyped. Genetic associations were estimated using logistic regression, adjusting for age, gender, and smoking history. The impact of genotypes on patients’ overall survival was analyzed with the Kaplan–Meier method with the log-rank test. Serum IL-1β concentration was determined by high sensitivity assay and expression analysis was done by RT-PCR. Decreased lung function, measured by a forced expiratory volume in 1 s (FEV1% predicted), was significantly associated with the minor allele genotypes (AT + TT) of NLRP1 rs12150220 (p = 0.0002). The same rs12150220 genotypes exhibited a higher level of serum IL-1β compared to the AA genotype (p = 0.027) in COPD patients. NLRP8 rs306481 minor allele genotypes (AG + AA) were more common in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) definition of group A (p = 0.0083). Polymorphisms in NLRP1 (rs12150220; OR = 0.55, p = 0.03) and NLRP4 (rs12462372; OR = 0.36, p = 0.03) were only nominally associated with COPD risk. In conclusion, coding polymorphisms in NLRP1 rs12150220 show an association with COPD disease severity, indicating that the fine-tuning of the NLRP1 inflammasome could be important in maintaining lung tissue integrity and treating the chronic inflammation of airways.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGenes
Numberingvol. 10, no. 10, 783
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes10100783
URN:NBNurn:nbn:hr:105:383052
Publication2019-10-09
Document URLhttps://www.mdpi.com/2073-4425/10/10/783
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-02-26 11:26:44