Tumors of the central nervous system are a heterogeneous group of benign and malignant tumors that can arise from brain tissue, meninges, cranial nerves, blood vessels or residual embryonic tissue and metastatic neoplasms. Tumors are classified according to the TNM and WHO classification. The World Health Organization (WHO) presented a new classification in 2016. which included molecular factors. Gliomas are the most common primary brain tumors in adults. Low-grade gliomas are, according to the WHO definition, grade I and grade II tumors. By examining the molecular profile of low-grade gliomas and with the realization that they have a relatively high potential of transformation to higher grade gliomas, the paradigm of treatment has changed. Neurosurgical treatment with adjuvant radiochemotherapy proved to be the best option. The goals of this research are multiple. The main goal is to show how different neurosurgical approaches affect the outcome of the disease and the frequency of recidivism. Specific research goals are to show the difference in the outcome after stereotactic biopsy and after open surgery, and to show the correlation between treatment outcomes and the application of adjuvant oncology therapy. Histological samples were obtained with a stereotactic biopsy, while other data were analyzed and obtained from the existing medical records. The results showed that the total resection of the tumor resulted in improvement of the life quality, and that in patients whose tumor was successfully completely removed, there was no recurrence of the disease. Patients whose tumor was not completely removed had a prolonged period of time without disease progression if adjuvant oncology treatment was administered.