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master's thesis
Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:723416
Sabljak, Petra
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Sabljak, P. (2019). Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:723416

Sabljak, Petra. "Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:723416

Sabljak, Petra. "Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde." Master's thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:723416

Sabljak, P. (2019). 'Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:723416

Sabljak P. Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:723416

P. Sabljak, "Prikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:723416

Metadata
TitlePrikaz serije bolesnika s primarnim limfomom nadbubrežne žlijezde
Title (english)Case series of patients with primary adrenal lymphoma
AuthorPetra Sabljak
MentorTina Dušek (mentor)
Committee memberDarko Kaštelan (predsjednik povjerenstva)
Committee memberSlavko Gašparov (član povjerenstva)
Committee memberTina Dušek (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract
Primarni limfom nadbubrežne žlijezde je izuzetno rijedak tumor. Bez obzira na njegovu rijetku pojavnost bitno ga je uvrstiti u diferencijalnu dijagnozu tumora nadbubrežne žlijezde. Ispravna i što ranija dijagnoza je ključna radi pravovremeno započetog kemoterapijskog liječenja. Dosad je u liječenju PAL-a najprimjenjivanija kemoterapijska shema R-CHOP. Neke od karakteristika PAL-a koje treba imati na umu pri diferencijalnog dijagnozi tumora nadbubrežne žlijezde su: starija životna dob bolesnika, prisutnost B simptoma, povišena razina LDH u serumu, bilateralna lokalizacija, adrenalna insuficijencija te negativni hormonskih testovi. Zbog svoje rijetke pojavnosti PAL često ne biva uvršten u diferencijalnu dijagnozu tumora nadbubrežne žlijezde te se liječenje započinje kirurškom resekcijom tumora, što je terapija izbora za češće prisutne malignome nadbubrežne žlijezde, adrenalni karcinom i feokromocitom. U ovom radu je opisano 5 slučajeva bolesnika s primarnim limfomom nadbubrežne žlijezde. Klinička prezentacija, karakteristike tumora, tijek liječenja, prognoza i preživljenje bolesnika iz slučajeva uspoređeni su sa slučajevima iz literature. Starost bolesnika pri dijagnozi je bila između 68 i 73 godine. Svi tumori su bili DLBCL podtipa. U jednom slučaju se radilo o bilateralno lokaliziranom tumoru uz prisutnu adrenalnu insuficijenciju, dok su je u 4 slučaja tumor bio unilateralne lokalizacije. Tri bolesnika su inicijalno liječena kirurškim zahvatom. Svim bolesnicima je tijekom liječenja ordinirana kemoterapija po CHOP i CHOP-u sličnim protokolima, međutim, samo je jedan bolesnik primio svih 6 ciklusa. Samo u jednog bolesnika je postignuta kompletna remisija bolesti.
Abstract (english)
Primary adrenal lymphoma is an extremely rare tumor. Regardless of its rare incidence, it is important to include PAL as a differential diagnosis of adrenal gland tumor. Correct and early diagnosis is essential for timely chemotherapeutic treatment. Nowadays, the most commonly used treatment of PAL is R-CHOP chemotherapy regimen. Some characteristics of PAL that should be considered in differential diagnosis are: elderly patients, presence of B symptoms, elevated LDH in serum, bilateral localization, adrenal insufficiency and negative hormonal tests. Because of its rare incidence PAL is often omitted from differential diagnosis of adrenal gland tumors and the primary treatment is often surgical resection, therapy of choice for the most common adrenal gland malignancy, adrenal carcinoma and heochromocytoma. In this paper five cases of PAL were presented. Clinical presentation, tumor characteristics, course of treatment, survival and prognosis in these cases were compared with literature. Age of patients at diagnosis was between 69 and 73. All tumors were DLBCL subtype. One patient had bilaterally localized tumor with adrenal insufficiency, while in 4 other cases tumors were unilateral. Three patients were initially treated surgically. To all patients CHOP or CHOP-like chemotherapy regimens were initiated, but only one patient received all 6 cycles. Complete remission was achieved in only one patient.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:723416
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-02 10:26:00