Title Promjena kvalitete života bolesnika s cirozom jetre nakon transplantacije
Title (english) Quality of life change in patients with liver cirrhosis after transplantation
Author Nino Kunac VIAF: 305796100
Mentor Tajana Filipec Kanižaj (mentor)
Committee member Rudolf Gregurek (predsjednik povjerenstva)
Committee member Boris Vucelić (član povjerenstva)
Committee member Leonardo Patrlj (član povjerenstva)
Granter University of Zagreb School of Medicine (Department of Internal Medicine) Zagreb
Defense date and country 2020-05-25, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Internal Medicine
Universal decimal classification (UDC ) 616 - Pathology. Clinical medicine
Abstract Cilj: Kvaliteta života primatelja jetre jedan je od najvažnijih parametara uspjeha transplantacijskog liječenja. Cilj ovog istraživanja bio je ispitati utjecaj prije i poslijetransplantacijskih kliničko-laboratorijskih obilježja i kvalitete presatka jetre na kvalitetu života primatelja jetre. -----
Metode i ispitanici: U istraživanje je uključeno 100 bolesnika s cirozom jetre dobi između 18 i 65 godina, transplantiranih u periodu 2015. do 2017. godine. Kvaliteta života procijenjena je generičkim -SF-36 i specifičnim upitnikom - CLDQ, koje su ispitanici ispunjavali prije transplantacije te 6 i 12 mjeseci nakon transplantacije. -----
Rezultati: U svim domenama SF-36 upitnika, osim u BP (p=0,582), te u svim domenama CLDQ upitnika, pokazano je da postoji statistički značajno poboljšanje kvalitete života uspoređujući stanje prije i nakon transplantacije jetre. Univarijatnom analizom se pokazalo da su faktori s pozitivnim utjecajem na kvalitetu života nakon transplantacije muški spol, etilična ciroza te viši CTP i MELD rezultat, dok su arterijska hipertenzija, HCC i viši DRI faktori s negativnim utjecajem. Spearmanova korelacija pokazala je statistički značajnu pozitivnu povezanost MELD rezultata s kvalitetom života 12 mjeseci nakon transplantacije u MCS domeni SF-36 upitnika (r=0,267, p=0,007), te u ukupnom rezultatu CLDQ upitnika (r=0,274, p=0,006). Multivarijatna raščlamba pokazala je da je značajno bolja kvaliteta života nakon transplantacije prisutna kod ispitanika s cirozom etilične geneze (p=0,037), te kod onih koji nemaju arterijsku hipertenziju (p=0,042). -----
Zaključak: Nakon transplantacije jetre dolazi do značajnog poboljšanja kvalitete života bolesnika. Faktori s pozitivnim utjecajem na kvalitetu života nakon transplantacije su muški spol, etilična ciroza te viši CTP i MELD rezultat, dok negativno utječu arterijska hipertenzija, HCC i viši DRI rezultat.
Abstract (english) Background: Quality of life is one of the most important success parameters after liver transplantation. The aim of this study was to evaluate the impact of pre- and post-transplantation clinical and laboratory parameters and liver graft quality on liver recipients quality of life. -----
Methods: The study comprised 100 patients with liver cirrhosis aged >18 and <65 years, transplantated in the period between year 2015 and 2017. Quality of life was assessed with a generic- SF-36 and specific questionnaire- CLDQ, at 3 times: before, and at 6 and 12 months after transplantation. -----
Results: We observed a significant improvement in quality of life after liver transplantation in all domains of SF-36, except in BP (p=0,582), and CLDQ questionnaire. Univariate analysis found that factors with positive effect on post-transplant quality of life are male gender, ethylic cirrhosis and higher CTP and MELD score, while arterial hypertension, HCC and higher DRI are factors with negative effect. Spearman analysis showed a significant positive correlation between MELD and results 12 months after transplantation, in the MCS SF-36 domain (r=0,267, p=0,007), and overall CLDQ domain (r=0,274, p=0,006). Multivariate analysis found significantly better post-transplant quality of life according to CLDQ overall domain, in patients with ethylic cirrhosis (p=0,037) and those without arterial hypertension (p=0,042). -----
Conclusion: Quality of life improved significantly after liver transplantation. Factors that positively affect post-transplant quality of life are male gender, ethylic cirrhosis and higher CTP and MELD score. Arterial hypertension, HCC and higher DRI are factors that adversely affect post-transplant quality of life.
Keywords
ciroza jetre
transplantacija jetre
kvaliteta života
Keywords (english)
liver cirrhosis
liver transplantation
quality of life
Language croatian
URN:NBN urn:nbn:hr:105:680306
Promotion 2021
Study programme Title: Biomedicine and Health Sciences Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Catalog URL https://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-09419?func=find-e&request=Promjena+kvalitete+%C5%BEivota+bolesnika+s+cirozom+jetre+nakon+transplantacije&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=72&y=13&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
Type of resource Text
Extent 103 str.
File origin Born digital
Access conditions Open access
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Created on 2021-03-04 09:36:55