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doctoral thesis
Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate
Zagreb: University of Zagreb, School of Medicine, 2020. urn:nbn:hr:105:927698
Petranović Ovčariček, Petra
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Petranović Ovčariček, P. (2020). Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:927698

Petranović Ovčariček, Petra. "Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate." Doctoral thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:927698

Petranović Ovčariček, Petra. "Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate." Doctoral thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:927698

Petranović Ovčariček, P. (2020). 'Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate', Doctoral thesis, University of Zagreb, School of Medicine, accessed 05 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:927698

Petranović Ovčariček P. Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2020 [cited 2024 November 05] Available at: https://urn.nsk.hr/urn:nbn:hr:105:927698

P. Petranović Ovčariček, "Funkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:105:927698

Metadata
TitleFunkcija štitnjače u bolesnika s novootkrivenim karcinomom prostate
Title (english)Thyroid function in patients with newly diagnosed prostate cancer
AuthorPetra Petranović Ovčariček
VIAF: 193146936625613780304
MentorTomislav Jukić (mentor)
Committee memberNikola Đaković (predsjednik povjerenstva)
Committee memberMaja Cigrovski Berković (član povjerenstva)
Committee memberMarijana Ćorić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2020-10-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Universal decimal classification
(UDC)		612 - Physiology
Abstract
U ovom istraživanju proučavala se povezanost trijodtironina (T3), slobodne frakcije tiroksina (fT4) te tireotropina (TSH) s diferenciranošću karcinoma prostate. Postavljena je hipoteza da su koncentracije T3 i fT4 veće, dok je koncentracija TSH manja u bolesnika sa slabije diferenciranim karcinomom. Ciljevi istraživanja bili su ustanoviti povezanost funkcije štitnjače i karcinoma prostate te otkrivanje mogućeg biomarkera slabije diferenciranosti, odnosno agresivnijeg oblika karcinoma. Dodatni ciljevi bili su utvrditi razliku u postotku tumora u tkivu prostate i patološkom T stadiju bolesti po radikalnoj prostatektomiji između skupina ispitanika s bolje i slabije diferenciranim karcinomom prostate. Ukupan broj ispitanika bio je 140, od kojih je 10 isključeno iz istraživanja zbog novootkrivene bolesti štitnjače, a pet zbog odustanka urologa i/ili ispitanika od zahvata. Ispitanici su podijeljeni u dvije skupine prema postoperativnom patohistološkom nalazu. Prvu skupinu (N=62) su činili bolesnici s karcinomom prostate Grade grupa 1 i 2 (bolje diferencirani karcinomi) a drugu skupinu (N=63) bolesnici s karcinomom prostate Grade grupa 3, 4 i 5 (slabije diferencirani karcinomi). Ustanovljeno je da je serumska koncentracija T3 statistički značajno veća u skupini ispitanika sa slabije diferenciranim karcinomom prostate (P=0,047). Ne postoji statistički značajna razlika u serumskim koncentracijama fT4 i TSH među dvjema skupinama ispitanika (P=0,68, P=0,801). Postotak tumora u tkivu prostate statistički je značajno veći u skupini ispitanika sa slabije diferenciranim karcinomom prostate (P<0,001). Isto tako, pT3 stadij bolesti je zastupljeniji u navedenoj skupini (P<0,001). T3 se nameće kao potencijalni biomarker slabije diferenciranosti karcinoma prostate, odnosno agresivnijeg oblika karcinoma, što je potrebno potvrditi studijama na većem broju ispitanika.
Abstract (english)
In this research, we studied the correlation of total triiodothyronine (T3), free fraction of the thyroxine (fT4), and thyrotropin (TSH) with prostate cancer (PCa) differentiation. We set the hypothesis that concentrations of T3 and fT4 are higher, while the TSH concentration is lower in patients with poorly differentiated PCa. Our goals were to determine the relationship between thyroid function and PCa, to detect the possible biomarkers of poorly differentiated PCa, and to determine the difference in the tumor percentage involvement (TPI) and pathological T (pT) stage of disease between the subjects with well-differentiated and poorly differentiated PCa. The total number of subjects was 140. Ten subjects were excluded from the study due to newly detected thyroid disease and 5 because of the withdrawal from the surgery. Subjects were divided into two groups according to postoperative histopathology. In the first group (N=62) there were patients with PCa Grade Groups 1 and 2 (well-differentiated cancer), while the second (N=63) group included patients with PCa Grade Groups 3, 4 and 5 (poorly differentiated cancer). Serum T3 concentration was significantly higher in poorly differentiated cancer group (P=0,047). There was no significant difference in concentrations of fT4 and TSH between the two groups (P=0,680, P=0,801, respectively). The TPI was significantly higher in poorly differentiated cancer group (P<0,001). Also, the pT3 stage of disease was more prevalent in the same group (P<0,001). T3 could serve as a potential biomarker of poorly differentiated PCa. However, larger studies should be conducted to confirm these findings.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:927698
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Catalog URLhttps://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-00649?func=find-e&request=Funkcija+%C5%A1titnja%C4%8De+u+bolesnika+s+novootkrivenim+karcinomom+prostate&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=34&y=15&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
Type of resourceText
Extent110 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-15 11:14:56