prikaz prve stranice dokumenta Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report
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Scientific paper - Case study
Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report
Iranian journal of parasitology, 14 (2019), 3; 492-496. urn:nbn:hr:105:278798
Skuhala, Tomislav; Trkulja, Vladimir; Runje, Mislav; Balen-Topić, Mirjana; Vukelić, Dalibor

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Skuhala, T., Trkulja, V., Runje, M., Balen Topić, M. & Vukelić, D. (2019). Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report. Iranian journal of parasitology, 14. (3), 492-496. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:278798

Skuhala, Tomislav, et al. "Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report." Iranian journal of parasitology, vol. 14, no. 3, 2019, pp. 492-496. https://urn.nsk.hr/urn:nbn:hr:105:278798

Skuhala, Tomislav, Vladimir Trkulja, Mislav Runje, Mirjana Balen Topić and Dalibor Vukelić. "Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report." Iranian journal of parasitology 14, no. 3 (2019): 492-496. https://urn.nsk.hr/urn:nbn:hr:105:278798

Skuhala, T., et al. (2019) 'Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report', Iranian journal of parasitology, 14(3), pp. 492-496. Available at: https://urn.nsk.hr/urn:nbn:hr:105:278798 (Accessed 23 November 2024)

Skuhala T, Trkulja V, Runje M, Balen Topić M, Vukelić D. Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report. Iranian journal of parasitology [Internet]. 2019 July [cited 2024 November 23];14(3):492-496. Available at: https://urn.nsk.hr/urn:nbn:hr:105:278798

T. Skuhala, V. Trkulja, M. Runje, M. Balen Topić and D. Vukelić, "Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report", Iranian journal of parasitology, vol. 14, no. 3, pp. 492-496, July 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:278798. [Accessed: 23 November 2024]

Metadata
Title (english)Combined Albenazole-Praziquantel Treatment in Recurrent Brain Echinococcosis: Case Report
AuthorTomislav Skuhala
AuthorVladimir Trkulja
AuthorMislav Runje
AuthorMirjana Balen-Topić
AuthorDalibor Vukelić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
We present a 40-year-old woman with a history of relapsing echinococcosis who had undergone a number of surgical procedures for cyst removal (right pulmectomy, cardiac surgery and 6 subsequent brain surgeries and two gamma knife procedures) and was admitted to University Hospital for Infectious Diseases "Fran Mihaljeviæ", Zagreb, Croatia in 2014 for pre-operative medical treatment of brain hydatidosis in the right parietal region. We aimed to attain a high cyst albendazole sulphoxide (ASO) concentration in order to achieve a more pronounced protoscolex inactivation and a high serum ASO concentration (reflecting the tissue concentrations) to reduce the risk of disease recurrence. The patient was treated with a higher dose of albendazole (15 mg/kg/day for 4 wk) that we had found effective in patients with liver hydatidosis, and combined with praziquantel over the last 14 d at a dose that is typically used to treat neurocysticercosis with an intention to improve ASO bioavailability. Neither serum nor cerebrospinal fluid concentrations on day 10 apparently differed from those on day 24 indicating a lack of an effect of praziquantel on ASO bioavailability. Intra-cystic ASO concentration was below the lower limit of quantification, but above the limit of detection. After the 7th episode of the disease and combined albendazole-praziquantel and surgery treatment, the patient achieved a 3-year remission. With the apparent lack of a meaningful pharmacokinetic praziquantel-albendazole interaction, this is most likely ascribable to the use of a higher albendazole dose than previously.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleIranian journal of parasitology
Numberingvol. 14, no. 3, pp. 492-496
p-ISSN1735-7020
e-ISSN2008-238X
URN:NBNurn:nbn:hr:105:278798
Publication2019-07
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815861/pdf/IJPA-14-492.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-03-17 09:08:05