Obesity is a major public health problem that has taken on pandemic proportions around the world. We define it as excessive accumulation of adipose tissue in the organism, respectively increase of body weight index over 30,00 kg/m². In the Republic of Croatia within this category we can place one fifth of the population whereas the world registers over 500 million people with obesity. Obesity increases the risk of many diseases such as diabetes, hypertension or malignant disease. Apart from this the economic burden of obesity is estimated to be at around 10% of total health care costs. Stress is unpleasant state of tension followed by physical and mental changes that arise as a response to events, situations or states that a person may estimate as dangerous or threatening for its mental and/or physical integrity. It is a risk factor for the development of cardio-vascular diseases and it deteriorates the flow of existing chronicle diseases such as diabetes, asthma and cardio-vascular diseases. There are more and more studies that show the clear connection between stress and obesity. Mechanism by which stress influences increase of body weight is complex and still not completely explained. Primarily it operates through modification of hypothalamus-pituitary-adrenal axis by which is partially regulated by sex hormones, that explains the difference in response to stress between sexes. Connection of stress to emotional neural network has been identified and in this manner throughout comfort food consummation, emotions have also influence on obesity. Increased risk for the development of obesity is registered within representatives of lower socio-economic status, in adulthood and childhood with more and more evidence that it is caused by stress.