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doctoral thesis
Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva
Zagreb: University of Zagreb, School of Medicine, 2020. urn:nbn:hr:105:060470
Antunac Golubić, Zrna
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Antunac Golubić, Z. (2020). Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:060470

Antunac Golubić, Zrna. "Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva." Doctoral thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:060470

Antunac Golubić, Zrna. "Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva." Doctoral thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:060470

Antunac Golubić, Z. (2020). 'Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva', Doctoral thesis, University of Zagreb, School of Medicine, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:060470

Antunac Golubić Z. Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2020 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:060470

Z. Antunac Golubić, "Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:105:060470

Metadata
TitlePrediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva
Title (english)Predictive significance of vitamin D in colorectal cancer patients
AuthorZrna Antunac Golubić
MentorStjepko Pleština (mentor)
Committee memberVesna Kušec (predsjednik povjerenstva)
Committee memberBorislav Belev (član povjerenstva)
Committee memberAntonio Juretić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2020-12-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Uvod: Istraživanja su pokazala da više koncentracije 25(OH)D u krvi smanjuju rizik za pojavu raka debelog crijeva. Bolesnici s metastatskim rakom debelog crijeva imaju često insuficijenciju D vitamina, ali utjecaj vitamina D na prognozu bolesti je još uvijek nerazjašnjen. U našem istraživanju smo analizirali povezanost primjene kolekalciferola u dozi od 2000 ij s preživljenjem bolesnika s metastatskim kolorektalnim karcinomom. ----- Ciljevi i metode istraživanja: U istraživanje je uključeno 72 bolesnika. Bolesnici s koncentracijom 25(OH)D < 75 nmol/L su randomizirani u dvije skupine : prva skupina je dobivala 2000 ij dnevno (do kraja praćenja) uz odgovarajuću onkološku terapiju, a druga samo odgovarajuću onkološku terapiju. Glavni cilj istraživanja bilo je ukupno preživljenje, a specifični ciljevi bili su vrijeme do progresije bolesti, prevalencija hipovitaminoze D te utjecaj kolekalciferola na serumsku koncentraciju 25(OH)D. ----- Rezultati: 98,1 % bolesnika je imalo hipovitaminozu D. Nije bilo razlike u OS i PFS među skupinama. Primjenom kolekalciferola u dozi 2000 ij nije došlo do adekvatnog porasta koncentracije 25(OH)D u krvi. ----- Zaključak: Većina bolesnika imala je hipovitaminozu D. Dodavanjem kolekalciferola 2000 ij dnevno kemoterapiji nismo poboljšali OS ni PFS.
Abstract (english)
Introduction: Some studies have demonstrated that higher baseline plasma levels of 25(OH)D are associated with a significant reduction in colorectal cancer (CRC) incidence. Patients with mCRC tend to be vitamin D insufficient, but the effect of vitamin D on the survival of mCRC patients still remains uncertain. In this study, we evaluated the association between cholecalciferol 2,000 IU daily supplementation and survival of mCRC patients. ----- Aims and methods: Seventy-two patients with mCRC were included. Seventy-one patients with 25(OH)D levels <75 nmol/L were randomized to receive standard chemotherapy or standard chemotherapy with cholecalciferol 2,000 IU daily for six months. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS) and prevalence of vitamin D insufficiency. ----- Results: All but one patient (98.6%) was vitamin D insufficient. There was no statistically significant difference in OS or PFS between those who received vitamin D supplements and controls. ----- Conclusions: The majority of patients with mCRC are vitamin D insufficient at the time of diagnosis. In our study, adding 2,000 IU of cholecalciferol daily for 2 yr to standard chemotherapy did not show any benefit in OS or PFS.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:060470
ProjectNumber: 108-1080058-0047
Title: Molekularni biljezi u solidnim tumorima - prediktivni i prognostički značaj
Title: The role of predictive and prognostic molecular markers in cancer treatment
Leader: Stjepko Pleština
Jurisdiction: Croatia
Funder: MZOS
Funding stream: ZP
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Catalog URLhttps://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-02476?func=find-e&request=Prediktivni+zna%C4%8Daj+odre%C4%91ivanja+koncentracije+vitamina+D+u+bolesnika+s+rakom+debeloga+crijeva&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=64&y=15&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
Type of resourceText
Extent83 str.
File originBorn digital
Access conditionsOpen access
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Created on2021-03-19 08:51:55