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doctoral thesis
Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:673015
Domislović, Viktor
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Domislović, V. (2021). Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:673015

Domislović, Viktor. "Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva." Doctoral thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:673015

Domislović, Viktor. "Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva." Doctoral thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:673015

Domislović, V. (2021). 'Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva', Doctoral thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:673015

Domislović V. Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:673015

V. Domislović, "Biomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:673015

Metadata
TitleBiomarkeri razgradnje i stvaranja kolagena III, IV i V u serumu kao pokazatelji upalne aktivnosti u bolesnika s upalnim bolestima crijeva
Title (english)Biomarkers of degradation and formation of collagen III, IV and V in serum as markers of inflammatory activity in patients with inflammatory bowel disease
AuthorViktor Domislović
VIAF: 43160242715552430914
MentorŽeljko Krznarić (mentor)
Committee memberSilvija Čuković-Čavka (predsjednik povjerenstva)
Committee memberMarko Banić (član povjerenstva)
Committee memberNeven Ljubičić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Ulcerozni kolitis (UC) i Crohnova bolest (CB) zahtijevaju kontinuiranu evaluaciju aktivnosti bolesti. Izvanstanični matriks (ECM) se sastoji od bazalne membrane koja se sastoji većinom od kolagena IV i intersticijskog matriksa u čijem se sastavu nalaze kolageni I, III i V. Patološko okruženje dovodi do narušenog remodeliranja, strukture, kvalitete i funkcije ECM-a. Naš cilj je bio istražiti biomarkere razgradnje i stvaranja kolagena i njihovu povezanost s aktivnosti bolesti u ispitanika s upalnim bolestima crijeva. U ovoj presječnoj studiji biomarkeri remodeliranja ECM-a izmjereni su u 162 ispitanika (110 CB i 52 UC). Biomarkeri razgradnje kolagena III (C3M) i stvaranja (Pro- C3), razgradnje kolagena IV (C4M) i stvaranja (Pro-C4) i stvaranja kolagena V (Pro- C5) izmjereni su metodom ELISA. Upalna aktivnost procijenjena je klinički, biokemijski i endoskopski. U aktivnoj upali prevladavaju procesi razgradnje kolagena III i IV i procesi stvaranja kolagena IV i V, dok u fazi remisije prevladava proces izgradnje kolagena III. Postoji razlika u profilu biomarkera izvanstaničnog matriksa u upalnim bolestima crijeva kada se upala definira koristeći endoskopske, kliničke ili biokemijske pokazatelje upalne aktivnosti. Biomarkeri C3M, Pro-C3 i C4M i njihova kombinacija mogli bi biti korisni u razlikovanju ispitanika s umjerenom do teškom aktivnosti bolesti od ispitanika u remisiji.
Abstract (english)
Ulcerative colitis (UC) and Crohn's disease (CD) require continuous evaluation of disease activity. Extracellular matrix (ECM) consists of basement membrane and interstitial matrix, which consist mainly of type IV collagen and types I, III and V collagen, respectively. Pathological environment leads to impaired remodeling, structure, quality and function of ECM. Our aim was to investigate biomarkers of collagen degradation and formation and their association with disease activity in patients with IBD. In this cross-sectional study, we have measured five biomarkers of ECM remodelling in 162 IBD patients (110 CD and 52 UC). Biomarkers of type III collagen degradation (C3M) and formation (Pro-C3), type IV collagen degradation (C4M) and formation (Pro-C4), and type V collagen formation (Pro-C5) were measured in serum by ELISA. Inflammatory activity was assesed using clinical, biochemical and endoscopic scores. We report pronounced process of collagen type III and IV degradation and collagen type IV and V formation in active disease, and formation of type III collagen in remission. There is a difference in ECM remodelling profile in IBD using clinical, biochemical and endoscopic activity indices. Combinatinon of biomarkers C3M, Pro-C3 and C4M could be useful in diferentiation patients with moderate to severe active disease from patients in remission.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:673015
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent83 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-24 13:14:48