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Scientific paper - Review paper
Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management
World Journal of Gastroenterology, 26 (2020), 21; 2740-2757. https://doi.org/10.3748/wjg.v26.i21.2740
Cigrovski Berković, Maja; Virović-Jukić, Lucija; Bilić-Ćurčić, Ines; Mrzljak, Anna

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Cigrovski Berković, M., Virović Jukić, L., Bilić Ćurčić, I. & Mrzljak, A. (2020). Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management. World Journal of Gastroenterology, 26. (21), 2740-2757. doi: 10.3748/wjg.v26.i21.2740

Cigrovski Berković, Maja, et al. "Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management." World Journal of Gastroenterology, vol. 26, no. 21, 2020, pp. 2740-2757. https://doi.org/10.3748/wjg.v26.i21.2740

Cigrovski Berković, Maja, Lucija Virović Jukić, Ines Bilić Ćurčić and Anna Mrzljak. "Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management." World Journal of Gastroenterology 26, no. 21 (2020): 2740-2757. https://doi.org/10.3748/wjg.v26.i21.2740

Cigrovski Berković, M., et al. (2020) 'Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management', World Journal of Gastroenterology, 26(21), pp. 2740-2757. doi: 10.3748/wjg.v26.i21.2740

Cigrovski Berković M, Virović Jukić L, Bilić Ćurčić I, Mrzljak A. Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management. World Journal of Gastroenterology [Internet]. 2020 July 07 [cited 2024 November 22];26(21):2740-2757. doi: 10.3748/wjg.v26.i21.2740

M. Cigrovski Berković, L. Virović Jukić, I. Bilić Ćurčić and A. Mrzljak, "Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management", World Journal of Gastroenterology, vol. 26, no. 21, pp. 2740-2757, July 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:289481. [Accessed: 22 November 2024]

Metadata
Title (english)Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management
AuthorMaja Cigrovski Berković
AuthorLucija Virović-Jukić
AuthorInes Bilić-Ćurčić
AuthorAnna Mrzljak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well-recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease (NAFLD), which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM. The metabolic risk factors including immunosuppressive drugs, can contribute to persistent or de novo development of DM and NAFLD after LT. T2DM, obesity, cardiovascular morbidities and renal impairment, frequently associated with metabolic syndrome and NAFLD, may have negative impact on short and long-term outcomes following LT. The treatment of DM in the context of chronic liver disease and post-transplant is challenging, but new emerging therapies such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Gastroenterology
Numberingvol. 26, no. 21, pp. 2740-2757
p-ISSN1007-9327
e-ISSN2219-2840
DOIhttps://doi.org/10.3748/wjg.v26.i21.2740
URN:NBNurn:nbn:hr:105:289481
Publication2020-07-07
Document URLhttps://www.wjgnet.com/1007-9327/full/v26/i21/2740.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-03-25 08:37:47