prikaz prve stranice dokumenta Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
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Scientific paper - Review paper
Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
The Neuroscientist, 27 (2021), 1; 10-29. https://doi.org/10.1177/1073858420921378
Carroll, Liam; Braeutigam, Sven; Dawes, John M.; Krsnik, Željka; Kostović, Ivica; Coutinho, Ester; Dewing, Jennifer M.; Horton, Christopher A.; Gomez-Nicola, Diego; Menassa, David A.

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Carroll, L., Braeutigam, S., Dawes, J. M., Krsnik, Ž., Kostović, I., Coutinho, E. ... Menassa, D. A. (2021). Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity. The Neuroscientist, 27. (1), 10-29. doi: 10.1177/1073858420921378

Carroll, Liam, et al. "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity." The Neuroscientist, vol. 27, no. 1, 2021, pp. 10-29. https://doi.org/10.1177/1073858420921378

Carroll, Liam, Sven Braeutigam, John M. Dawes, Željka Krsnik, Ivica Kostović, Ester Coutinho, Jennifer M. Dewing, Christopher A. Horton, Diego Gomez Nicola and David A. Menassa. "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity." The Neuroscientist 27, no. 1 (2021): 10-29. https://doi.org/10.1177/1073858420921378

Carroll, L., et al. (2021) 'Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity', The Neuroscientist, 27(1), pp. 10-29. doi: 10.1177/1073858420921378

Carroll L, Braeutigam S, Dawes JM, Krsnik Ž, Kostović I, Coutinho E, and sur.. Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity. The Neuroscientist [Internet]. 2021 February [cited 2024 November 23];27(1):10-29. doi: 10.1177/1073858420921378

L. Carroll, et al., "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity", The Neuroscientist, vol. 27, no. 1, pp. 10-29, February 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:570841. [Accessed: 23 November 2024]

Metadata
Title (english)Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
AuthorLiam Carroll
AuthorSven Braeutigam
AuthorJohn M. Dawes
AuthorŽeljka Krsnik
AuthorIvica Kostović
AuthorEster Coutinho
AuthorJennifer M. Dewing
AuthorChristopher A. Horton
AuthorDiego Gomez-Nicola
AuthorDavid A. Menassa
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders of genetic and environmental etiologies. Some ASD cases are syndromic: associated with clinically defined patterns of somatic abnormalities and a neurobehavioral phenotype (e.g., Fragile X syndrome). Many cases, however, are idiopathic or non-syndromic. Such disorders present themselves during the early postnatal period when language, speech, and personality start to develop. ASDs manifest by deficits in social communication and interaction, restricted and repetitive patterns of behavior across multiple contexts, sensory abnormalities across multiple modalities and comorbidities, such as epilepsy among many others. ASDs are disorders of connectivity, as synaptic dysfunction is common to both syndromic and idiopathic forms. While multiple theories have been proposed, particularly in idiopathic ASDs, none address why certain brain areas (e.g., frontotemporal) appear more vulnerable than others or identify factors that may affect phenotypic specificity. In this hypothesis article, we identify possible routes leading to, and the consequences of, altered connectivity and review the evidence of central and peripheral synaptic dysfunction in ASDs. We postulate that phenotypic specificity could arise from aberrant experience-dependent plasticity mechanisms in frontal brain areas and peripheral sensory networks and propose why the vulnerability of these areas could be part of a model to unify preexisting pathophysiological theories.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleThe Neuroscientist
Numberingvol. 27, no. 1, pp. 10-29
p-ISSN1073-8584
e-ISSN1089-4098
DOIhttps://doi.org/10.1177/1073858420921378
URN:NBNurn:nbn:hr:105:570841
Publication2021-02
Document URLhttp://journals.sagepub.com/doi/10.1177/1073858420921378
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-03-29 10:31:42