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doctoral thesis
Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:253641
Madžarac, Zoran
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Madžarac, Z. (2021). Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:253641

Madžarac, Zoran. "Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom." Doctoral thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:253641

Madžarac, Zoran. "Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom." Doctoral thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:253641

Madžarac, Z. (2021). 'Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom', Doctoral thesis, University of Zagreb, School of Medicine, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:253641

Madžarac Z. Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:105:253641

Z. Madžarac, "Povezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:253641

Metadata
TitlePovezanost polimorfizma gena za katehol-O-metil transferazu i monoaminooksidazu tipa B s anhedonijom u bolesnika sa shizofrenijom
Title (english)The association between catechol-O-methyl transferase and monoamine oxidase type B gene polymorphisms and anhedonia in patients with schizophrenia
AuthorZoran Madžarac
MBZ: 289595
MentorMarina Šagud (mentor)
MentorNela Pivac (komentor)
Committee memberAlma Mihaljević-Peleš (predsjednik povjerenstva)
Committee memberNada Božina (član povjerenstva)
Committee memberDalibor Karlović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2021-02-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj ovog istraživanja je bio istražiti povezanost polimorfizama za katehol-O-metil transferazu (COMT) rs4680 i rs4818 i monoaminooksidazu tipa B (MAO-B) rs1799836 i rs6651806 s anhedonijom i drugim negativnim simptomima kod bolesnika sa shizofrenijom. Presječno istraživanje obuhvatilo je 302 bolesnika (58.9% muških, medijan godina 42). Glavni rezultati: nositeljice G alela (povezanog s većom aktivnošću COMT-a) za COMT rs4680 i rs4818 imale su izraženije negativne simptome u odnosu na ispitanice bez G alela. COMT rs4818-rs4680 haplotip G-G je kod ispitanica bio povezan s izraženijim negativnim simptomima. Muški nositelji MAO-B rs1799836 A alela imali su izraženiju alogiju prema nositeljima G alela. Ispitanice s fizičkom i socijalnom anhedonijom imale su veću frekvenciju pojavljivanja MAO-B rs6651806 A alela od ispitanica bez navedenih podtipova anhedonije, ali su nositeljice A alela imale manje depresivnih simptoma od nositeljica C alela. Muški nositelji MAO-B rs6651806 A alela imali su izraženije negativne simptome nego nositelji C alela, dok je MAO-B rs1799836-rs6651806 haplotip G-C kod muških ispitanika bio povezan s manje izraženim negativnim simptomima. Zaključno, rezultati istraživanja pokazali su postojanje složene i spolno specifične povezanosti polimorfizama COMT i MAO-B i anhedonije te negativnih simptoma u shizofreniji, te ističu povezanost između slabog istraženog polimorfizma MAO-B rs6651806 i određenih skupina simptoma shizofrenije.
Abstract (english)
The aim of the study was to investigate the association of catechol-O-methyl transferase (COMT) rs4680 and rs4818, and monoamine oxidase type B (MAO-B) rs1799836 and rs6651806 polymorphisms, with anhedonia and other negative symptoms in patients with schizophrenia. This cross-sectional study included 302 patients (58.9% males, median age 42). Main findings: Female carriers of the COMT rs4680 and rs4818 G-allele (related to higher COMT activity) had more severe negative symptoms, compared to females without G allele. COMT rs4818-rs4680 G-G haplotype in females was associated with more severe negative symptoms. Male MAO-B rs1799836 A-allele carriers had more severe alogia than G-allele carriers. Females with physical and social anhedonia had higher frequency of MAO-B rs6651806 A-allele, than females without such anhedonia subtypes, but female A-allele carriers had less severe depressive symptoms than C-allele carriers. Male carriers of MAO-B rs6651806 A-allele had more prominent negative symptoms than C-allele carriers, while MAO-B rs1799836-rs6651806 G-C haplotype in males was associated with less severe negative symptoms. Those findings implicate complex, but sex-specific associations between COMT and MAO-B polymorphisms with anhedonia and negative symptoms in schizophrenia, and highlight the relationship between poorly known MAO-B rs6651806 polymorphism and several symptom domains in schizophrenia.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:253641
Promotion2021
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent130 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-12 10:06:47