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master's thesis
PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature
Zagreb: University of Zagreb, School of Medicine, 2020. urn:nbn:hr:105:084849
Hodak, Kristian
University of Zagreb
School of Medicine
Department of Pediatrics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Hodak, K. (2020). PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:084849

Hodak, Kristian. "PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature." Master's thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:084849

Hodak, Kristian. "PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature." Master's thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:084849

Hodak, K. (2020). 'PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature', Master's thesis, University of Zagreb, School of Medicine, accessed 30 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:084849

Hodak K. PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2020 [cited 2024 November 30] Available at: https://urn.nsk.hr/urn:nbn:hr:105:084849

K. Hodak, "PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:105:084849

Metadata
TitlePANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature
Title (english)PANDAS: diagnostic and therapeutic challenges, case report and literature review
AuthorKristian Hodak
MentorMarija Jelušić (mentor)
Committee memberJurica Vuković (predsjednik povjerenstva)
Committee memberIrena Senečić-Čala (član povjerenstva)
Committee memberMarija Jelušić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Zagreb
Defense date and country2020-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Pedijatrijski autoimunosni neuropsihijatrijski poremećaji udruženi sa streptokoknom infekcijom (PANDAS, engl. pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) predstavljaju kontroverzni klinički entitet u medicinskoj praksi zbog nedovoljno poznate etiopatogeneze, nepostojanja specifičnog biljega za potvrdu dijagnoze te teško dokazive uzročno-posljedične veze između infekcije ß-hemolitičkim streptokokom skupine A (BHSA) i pojave simptoma ovog poremećaja. Očituje se naglo nastalim simptomima i znakovima opsesivno-kompulzivnog poremećaja (OKP) i/ili tikovima, a koji su povezani s nedavnom infekcijom BHSA-om. U radu smo prikazali bolesnicu s PANDAS-om uz kratak pregled literature vezano uz etiopatogenezu, dijagnostiku i liječenje pri čemu smo željeli naglasiti složenost ovog poremećaja zbog velikih različitosti u kliničkoj slici, nemogućnosti postavljanja sigurne dijagnoze i prijepora u odabiru učinkovitih metoda liječenja. Iz navedenoga je razvidno da mnoga pitanja u svezi s PANDAS-om ostaju otvorena te da su potrebna daljnja istraživanja i multidisciplinarni pristup kako bi se bolje upoznao ovaj kompleksni klinički entitet.
Abstract (english)
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial clinical entity in medical practice due to insufficiently known etiopathogenesis, lack of specific markers for confirmation of the diagnosis, and difficult-to-prove causal relationship between a group A ß-haemolytic streptococcal (GABHS) infection and the onset of symptoms. It presents with a sudden onset of symptoms and signs of obsessive-compulsive disorder (OCD) and/or tics, which are associated with a recent GABHS infection. We presented a patient with PANDAS as well as a brief overview of the literature concerning the etiopathogenesis, diagnostics and treatment while emphasizing the complexity of this disorder due to the large variations in clinical presentation, the inability to make a reliable diagnosis, and the controversies in choosing effective treatment methods. It is evident that many of the issues surrounding PANDAS remain open and that further research and a multidisciplinary approach are needed to better understand this complex clinical entity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:084849
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-13 08:31:19