Depressive disorder is very frequent, because of the fast and stressful way of modern life, which is considered to be among major risk factors in developing depression. Depression has a significant impact on function, leading to difficulties in performing everyday activities even the most basic ones. However, patients are not the only ones affected by depression. It is the disease of the whole family. While thousands of papers have been published regarding depressed patients, their caregivers have been neglected. However, they also suffer due to consequences of this devastating disorder. Depressive disorder has a huge impact on communication with kith and kin. Depression deteriorates the quality of life of family members. It also adversely influences other significant areas of life, such as financial state, which puts caregivers into difficult situation. Caring for a person with symptoms of depression is already known to be a heavy burden. Therefore, several studies have been carried out to recognize the most relevant problems and develop effective strategies to maintain a good quality life despite the presence of depressive disorder in the family. Those studies provided a number of interesting results. The importance of measuring the impact of depression on caregivers has been highlighted. Better understanding of their duties can make significant contribution to the development of novel strategies that would aid the recovery of the patient, as well as contribute to the improvement of quality of life of both patients and their caregivers. In addition, it has been observed that schools, workplaces, social community and the health care system all have an important role in educating the family and other individuals about the signs and symptoms of depression and also in providing the optimal care. All studies unequivocally reported that caregivers are particularly vulnerable population, which has many unmet needs, such as professional assistance, and, above all, a warm word and understanding.