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Scientific paper - Original scientific paper
HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia
International Journal of Molecular Sciences, 21 (2020), 7; 2345. https://doi.org/10.3390/ijms21072345
Grubor, Mirko; Živković, Maja; Šagud, Marina; Nikolac Perković, Matea; Mihaljević-Peleš, Alma; Pivac, Nela; Muck-Šeler, Dorotea; Švob Štrac, Dubravka

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Grubor, M., Živković, M., Šagud, M., Nikolac Perković, M., Mihaljević Peleš, A., Pivac, N. ... Švob Štrac, D. (2020). HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. International Journal of Molecular Sciences, 21. (7). doi: 10.3390/ijms21072345

Grubor, Mirko, et al. "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia." International Journal of Molecular Sciences, vol. 21, no. 7, 2020. https://doi.org/10.3390/ijms21072345

Grubor, Mirko, Maja Živković, Marina Šagud, Matea Nikolac Perković, Alma Mihaljević Peleš, Nela Pivac, Dorotea Muck Šeler and Dubravka Švob Štrac. "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia." International Journal of Molecular Sciences 21, no. 7 (2020). https://doi.org/10.3390/ijms21072345

Grubor, M., et al. (2020) 'HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia', International Journal of Molecular Sciences, 21(7). doi: 10.3390/ijms21072345

Grubor M, Živković M, Šagud M, Nikolac Perković M, Mihaljević Peleš A, Pivac N, and sur.. HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. International Journal of Molecular Sciences [Internet]. 2020 March 28 [cited 2025 March 14];21(7). doi: 10.3390/ijms21072345

M. Grubor, et al., "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia", International Journal of Molecular Sciences, vol. 21, no. 7, March 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:380748. [Accessed: 14 March 2025]

Metadata
Title (english)HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia
AuthorMirko Grubor
AuthorMaja Živković
AuthorMarina Šagud
AuthorMatea Nikolac Perković
AuthorAlma Mihaljević-Peleš
AuthorNela Pivac
AuthorDorotea Muck-Šeler
AuthorDubravka Švob Štrac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse reactions to antipsychotic medications. In addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-HT) receptors, might be involved in EPS development. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two... More weeks of haloperidol monotherapy. The Simpson–Angus Rating Scale for Extrapyramidal Side Effects (SAS), Barnes Akathisia Rating Scale (BARS) and Extrapyramidal Symptom Rating Scale (ESRS) were used to evaluate EPS severity. Genotyping was performed using real-time PCR, following extraction of blood DNA. Significant acute EPS appeared in 48.03% of schizophrenia patients. For the rs13212041 HTR1B gene polymorphism, affecting microRNA regulation of HTR1B gene expression, a higher frequency of TT carriers was found among haloperidol-treated patients with akathisia when compared to the group without akathisia symptoms. In comparison to C-allele carriers, patients carrying the TT genotype had higher akathisia severity, as determined by the SAS, BARS and ESRS scales. These molecular findings suggest potential involvement of 5-HT1B receptors in akathisia development following haloperidol treatment, as well as possible epigenetic mechanisms of serotonergic modulation associated with antipsychotic-induced EPS. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 21, no. 7, 2345
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21072345
URN:NBNurn:nbn:hr:105:380748
Publication2020-03-28
Document URLhttps://www.mdpi.com/1422-0067/21/7/2345
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-04-19 11:50:09
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