prikaz prve stranice dokumenta Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol
  Download
PDF 317.37 KB
Scientific paper - Original scientific paper
Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol
Journal of Obstetrics and Gynaecology Research, 47 (2021), 3; 992-1001. https://doi.org/10.1111/jog.14626
Šprem Goldštajn, Marina; Dumančić, Stipe; Mikuš, Mislav

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šprem Goldštajn, M., Dumančić, S. & Mikuš, M. (2021). Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol. Journal of Obstetrics and Gynaecology Research, 47. (3), 992-1001. doi: 10.1111/jog.14626

Šprem Goldštajn, Marina, et al. "Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol." Journal of Obstetrics and Gynaecology Research, vol. 47, no. 3, 2021, pp. 992-1001. https://doi.org/10.1111/jog.14626

Šprem Goldštajn, Marina, Stipe Dumančić and Mislav Mikuš. "Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol." Journal of Obstetrics and Gynaecology Research 47, no. 3 (2021): 992-1001. https://doi.org/10.1111/jog.14626

Šprem Goldštajn, M., Dumančić, S. and Mikuš, M. (2021) 'Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol', Journal of Obstetrics and Gynaecology Research, 47(3), pp. 992-1001. doi: 10.1111/jog.14626

Šprem Goldštajn M, Dumančić S, Mikuš M. Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol. Journal of Obstetrics and Gynaecology Research [Internet]. 2021 March [cited 2024 May 14];47(3):992-1001. doi: 10.1111/jog.14626

M. Šprem Goldštajn, S. Dumančić and M. Mikuš, "Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol", Journal of Obstetrics and Gynaecology Research, vol. 47, no. 3, pp. 992-1001, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:804880. [Accessed: 14 May 2024]

Metadata
Title (english)Retrospective analysis of the use of two recombinant follitropin alfa injections in patients undergoing in vitro fertilization treatment with the gonadotropin‐releasing hormone antagonist protocol
AuthorMarina Šprem Goldštajn
AuthorStipe Dumančić
AuthorMislav Mikuš
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Aim: To evaluate the clinical efficacy of biosimilar (Ovaleap) compared with the referenced follitropin alfa (Gonal-f), within the context of antagonistic multiple doses protocol of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques. ----- Methods: A retrospective, monocentric study included 229 infertile women aged 22 to 43 years who underwent their first cycle of COH for the purpose of the IVF or ICSI during the period of 2017. Eligible patients underwent ovarian stimulation with either Ovaleap (n = 152) or Gonal-f (n = 77) starting at Cycle Day 2 and were receiving gonadotropin-releasing hormone (GnRH) antagonist in either fixed or flexible antagonist protocol manner. ----- Results: Ovaleap-treatment resulted in fewer number of oocytes retrieved in regard to Gonal-f-treatment, with the median of seven oocytes retrieved in the Ovaleap group versus nine in the Gonal-f group (U = 5369.5, P = 0.3079). Clinical pregnancy rate was 24.3% in the overall study sample and 31.9% in women with embryo transfer, in the Ovaleap group. Similarly, in the Gonal-f group these rates were 25.0% and 34.5%, respectively. Only four patients experienced ovarian hyperstimulation syndrome, with one case in Ovaleap-treatment group and three cases in Gonal-f-treatment group. ----- Conclusion: While the clinical efficacy profile favored using Gonal-f formulation of follitropin alfa, this analysis showed that there is no significant difference in the number of oocytes retrieved between Ovaleap and Gonal-f follitropin alfa formulations, used within GnRH antagonist protocols of COH.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Obstetrics and Gynaecology Research
Numberingvol. 47, no. 3, pp. 992-1001
p-ISSN1341-8076
e-ISSN1447-0756
DOIhttps://doi.org/10.1111/jog.14626
URN:NBNurn:nbn:hr:105:804880
Publication2021-03
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/jog.14626
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-06-01
Terms of useLicence In copyright icon
Created on2021-04-21 14:11:49