A modern treatment and control of chronic non-communicable diseases who include asthma requires a holistic approach and includes objective and subjective opinion of the clinical indicators of HRQOL assessment acknowledges that often do not correlate. The ultimate goal of in the treatment is a acquiring control of the disease and improve the overall quality of life. Asthma is a a chronic disease, and each child's changing family dynamics and functioning of previous models and requires an adjustment from parents and child. The attitude towards the disease and response of the child are largely determined behavior of the parents therefore in the process of treating asthma child regardless of age, it is necessary to actively involve family members especially their parents. The main objective of this research to investigate and compared perceptions of the quality of life of children with asthma and their parents, and to determine what the specific association between objective indicators and the results of the quality of life of parents and children. A cross-sectional study was conducted over a period of four months in the year 2014 at the General Hospital Virovitica, in the infirmary of the Children's Department. Participants were children aged 7-17 years that came to medical examination (n = 108) by their parents (n = 97). This work were used the specific instruments to measure HRQOL in asthma for children and their parents PAQLQ PACQLQ in three areas / domains - actions, emotions and symptoms. In addition, parents completed a questionnaire on sociodemographic characteristics. Based on the results, the perception of the quality of life of children and parents is significantly different, with the children expressed greater satisfaction with the quality of life from their parents. The parents higher level of education expressed greater satisfaction with the quality of life. Comorbidity and partly controlled asthma reduces the quality of life in children. The children with controlled asthma were significantly older than children with a partially controlled asthma, the value of the overall quality of life were significantly higher in older kids.