World Health Organization and International Pharmaceutical Federation define selfmedication as a practice where an individual selects and uses medicines for self-diagnosed symptoms and minor illnesses. In hole world and especially in developing countries governments and health policies are encouraging self-medication practice to reduce health expenditure and so physicians could focus on serious health problems. In theory, there are many risks of self-medication. Self-medication includes self-diagnosis which can be incorrect and can cause delay of appropriate treatment. Medicines used for selfdiagnosis should be of high standard of safety. Medicines used are those indicated for conditions that are self-recognizable and for some chronic or recurrent conditions. In all cases, these medicines should be specifically designed for the purpose, and will require appropriate dose and dosage forms. Aim of this study is to examine out of pocket expenditure on nonprescription medicines and food supplements in pharmacy and to determine whether the purchase is associated with socioeconomic and sociodemographic factors. The survey was conducted on a sample of 200 respondents. The questionnaire answered 185 people and 15 did not complete the questionnaire. (The response rate was 92.5%). The study was conducted on patients at Pharmacies Pavlić, which consists of three pharmacy units: two pharmacy units in Sisak and one branch in Martinska Ves, who entered the pharmacy between July 1st and September 1st, 2016. In this study, we have associated virtually all socioeconomic and sociodemographic factors with the purchase of non-prescription drugs, but we have not found such a connection with dietary supplements. The groups that should be in focus of public health campaigns and education on the safe use of non-prescription drugs should be women and people with higher socioeconomic status. Also, we have identified a possible source of health inequality in the future as more medicines are switched to nonprescription status and governments encourage out of pocket expenditure on medications.