Drug hypersensitivity reactions are a common clinical problem. Each administered drug, in addition to its beneficial effect, can also develop side effects. The fact is that the number of new drugs is constantly growing, that life expectancy is extended and that treatment is often carried out according to strictly defined guidelines, which results in taking more drugs, thereby increasing the risk of allergies, side effects and drug interactions. The occurrence of a hypersensitivity reaction is influenced by the method of drug administration, the duration of treatment, the dose of the drug and the frequency of drug administration. Factors for the occurrence of an allergic reaction can be by the drug (chemical structure of the drug, most often antibiotics and NSAIDs) and patients (age, gender, genetics, previous drug allergies). Clinically it manifests itself in the form of skin changes, swelling of the mucous membranes soft tissue (tongue, mouth), bronchospasm, all the way to anaphylaxis, a lifethreatening allergic reaction. Precise identification of the responsible drug is important to avoid its future use or to allow the use of an incorrectly “guilty” drug that may be denied to the patient. Our Department performs skin tests prick and I.D. (beta lactam antibiotics, contrast agents, local and general anesthetics, vaccines, biological drugs etc.), oral exposure (antibiotics, analgesics, antihypertensives, statins, IPP, antiepileptics etc.) in increasing concentrations to full unit doses. Exposure is the gold standard in drug hypersensitivity testing. Only a well-educated, trained and experienced nurse can adequately conduct skin and provocative testing according to which an objective conclusion about hypersensitivity can be made. Nurses and doctors team work can bring benefit to each patient.