Detection, treatment and follow-up of patients with arterial hypertension is an indispensable part of the daily work of a family medicine specialist, since the work of this type of medical professional implies a comprehensive approach, communication skills and continuity of care. Due to the high prevalence of this chronic disease as well as a number of potential complications, it is important to detect and begin treatment of this chronic disease in a timely manner. A detailed anamnesis and thorough laboratory processing are, in addition to knowing the correct technique for measuring blood pressure, important components of a dedicated approach to a high-risk patient. A good care plan for a patient with high blood pressure in family medicine involves using guidelines based on evidence-based medicine as well as adhering to the principles of person-centered care. In addition to the pharmacological approach, which usually involves a fixed combination of drugs, it is necessary to adjust the patient's approach and point out the importance of diet, exercise and a healthy lifestyle in order to make changes in habits and lifestyle. A well-organized health care system, a doctor with specialist training in family medicine and a patient trained for their own condition are prerequisites for good outcomes in the treatment of this type of chronic patients. Without these conditions, implementing knowledge of drug combinations will not result in success. For treatment to be successful, patient compliance and adherence to pharmacotherapy must be satisfactory. With specific questionnaires within the infirmary, the doctor is able to assess the patient's adherence to the drug as well as to show his own interest and care for the patient. Ease of administration and reduction in the quantity of a certain drug, clarity of instructions and involvement of the patient to actively participate in the creation of a treatment plan show a good therapeutic outcome. The use of fixed combinations in the treatment of arterial hypertension achieves better control of arterial pressure with fewer side effects, greater adherence and patient satisfaction as well as better control of comorbid conditions.