In recent years, a great deal of interest towards spirituality can be found in medicine and particularly psychiatry. Spirituality is becoming a major subject of scientific debate and research. A large number of scientifically substantiated facts about the positive effects of spirituality on healing and recovery of patients can be found. Positive values of spirituality are mentioned, which, among other things, reduce the hospitalization and recovery times and positively impact the adaptation of patients to the disease. For people in the oldest known civilizations, spirituality represented a source of strength and a skill which aided their struggle against the sufferings of life and diseases. Spirituality cannot be excluded from the overall human existence because, in addition to the psychological and physical dimensions, it forms a human being in its entireness. A human being needs to be observed through all three mentioned dimensions because each of them is equally important and valuable. Spirituality is increasingly present in the treatment of psychiatric patients because it has proven to be an effective and important component in the health care process. The strength of human spirituality is in accepting the illness and suffering as a means to achieve the spiritual growth and self-transcendence. Furthermore, the power of spirituality is in finding not only the meaning of life in general, but also the meaning of suffering and disease. The meaning of life is present in every life situation and requires to be found. Finding meaning is the individual responsibility and life task of each person. Psychiatry, religion and spirituality are disjoint disciplines and they need to be joined together. Although different, each of them provides specific insights with valuable items which ultimately form an indivisible whole which is essential in working with psychiatric patients. Nowadays, psychiatry and spirituality can contribute much to building a healthier society. An essential link of a medical team taking care for psychiatric patients is a nurse. With her knowledge, experience and skills, the nurse aids the recovery of the patient and minimizes the unwanted factors within the hospitalization process. The nurse should show a holistic approach to the psychiatric patient and view him, primarily as an individual person, and only then as a patient. Thanks to spending most of her time with the patient, the nurse can recognize and understand the patient’s needs. The nurse should recognize the importance of spiritual and religious beliefs of the patient, act respectfully towards his beliefs, and direct the planned interventions for the benefit of physical and spiritual conditions of the patient. Spirituality is an essential component of human life and should not be neglected during the psychiatric treatment.