| Abstract | Uvod i cilj istraživanja: Zbog neselektivnog djelovanja citostatika tijekom primanja
kemoterapije, javljaju se neželjene posljedice koje mogu utjecati na liječenje i kvalitetu
života oboljelih. Cilj ovog istraživanja bio je ispitati povezanost promjene osjeta okusa
i kvalitetu života kod bolesnika koji primaju kemoterapiju.
Ispitanici i metode: Presječno istraživanje provedeno je na prigodnom uzorku ispitanika
(N = 258) u Dnevnoj bolnici, Klinike za onkologiju, Kliničkog bolničkog centra Zagreb.
Ispitanici su popunjavali tri upitnika. Upitnik o sociodemografskim podacima i tijeku
liječenja, upitnik o kvaliteti života onkoloških bolesnika (EORTC QLQ-C30) i Skalu za
procjenu promjena osjeta okusa izazvanih kemoterapijom (CiTAS). Analiza podataka
provedena je u programu SPSS 20.
Rezultati: Istraživanjem je bilo obuhvaćeno 102 ispitanika (73,5 % žena) koji su pristali
na sudjelovanje u istraživanju (obuhvat 39,5 %), prosječne dobi 55,10 godina.
Najčešće primarno sijelo raka bila je dojka (64,7 %). Kao vrstu kemoterapije, najviše
ispitanika primalo je paklitaksel (45,1 %). Rezultati na Skali za procjenu promjena
osjeta okusa izazvanih kemoterapijom bili su umjereno negativno povezani s
rezultatom na skali općeg zdravlja/kvalitete života. Najveća povezanost između
promjena u osjetu okusa bila je s nižim kognitivnim funkcioniranjem (r = -0,47; p <
0,001). Najviše korelacije između ukupnog rezultata na CiTAS skali bile su sa
simptomom mučnine i povraćanja (r = 0,51; p < 0,001) te s gubitkom apetita (r = 0,49;
p < 0,001). Nisu pronađene razlike ni na jednoj dimenziji CiTAS skale s obzirom na
vrstu kemoterapije koju bolesnici primaju, niti povezanost s dobi.
Zaključak: Rezultati istraživanja su pokazali da ispitanici s izraženim promjenama u
osjetu okusa imaju niže procjene općeg zdravlja/kvalitete života. Promjene u osjetu
okusa nisu bile povezane s vrstom kemoterapije i dobi. Rezultati istraživanja ukazuju
na potrebu dodatne edukacije pacijenata o svim nuspojavama koje se mogu javiti kao
posljedica primanja kemoterapije. Protokol i instrumenti korišteni u ovom istraživanju
mogu poslužiti za odgovarajuće intervencije u pacijenata koji primaju kemoterapiju. |
| Abstract (english) | Introduction and aim of the study: Due to the non-selective action of cytostatics during
the reception of chemotherapy, side effects occur that can affect the treatment and
quality of life of patients. The aim of this study was to examine the association between
changes in taste perception and quality of life in patients receiving chemotherapy.
Subjects and methods: A cross-sectional study was conducted on a sample of subjects
(N = 258) in the Outpatient Clinic, Department of Oncology, the University Hospital
Centre in Zagreb. The respondents completed three questionnaires.
Sociodemographic data and course of treatment questionnaire, quality of life
questionnaire for oncology patients (EORTC QLQ-C30) and Chemotherapy-induced
taste alteration scale (CiTAS). Data analysis was performed in SPSS 20.
Results: The study included 102 respondents (73.5 % women) who agreed to
participate in the study (coverage 39.5 %), average age 55.10 years. The most
common primary site for cancer were breast (64.7 %). As a type of chemotherapy,
most subjects received chemotherapy with Paclitaxel (45.1 %). The results on the
chemotherapy-induced taste alteration scale were moderately negatively correlated
with the result on the general health and health-related quality of life scale. The
greatest association between changes in taste perception was with lower cognitive
functioning (r = -0.47; p < 0.001). The highest correlations between the overall CiTAS
score were with the symptoms of nausea and vomiting (r = 0.51; p < 0.001) and with
loss of appetite (r = 0.49; p < 0.001). No differences were found on any dimension of
the CiTAS scale with respect to the type of chemotherapy patients receive, nor the
association with age.
Conclusion: The results of the study showed that subjects with pronounced changes
in taste perception have lower assessments of general health/quality of life. Changes
in taste perception were not associated with type of chemotherapy and age. The results
of the study indicate the need for additional education of patients on side effects that
may occur as a result of receiving chemotherapy. The protocol and instruments used
in this study may serve for appropriate interventions in patients receiving
chemotherapy. |
