prikaz prve stranice dokumenta Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
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Scientific paper - Original scientific paper
Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
Free Radical Biology and Medicine, 162 (2021); 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024
Konjevod, Marcela; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Sáiz, Jorge; Tudor, Lucija; Uzun, Suzana; Kozumplik, Oliver; Švob Štrac, Dubravka; Žarković, Neven; Pivac, Nela

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Konjevod, M., Nedić Erjavec, G., Nikolac Perković, M., Sáiz, J., Tudor, L., Uzun, S. ... Pivac, N. (2021). Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans. Free Radical Biology and Medicine, 162., 636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

Konjevod, Marcela, et al. "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans." Free Radical Biology and Medicine, vol. 162, 2021, pp. 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024

Konjevod, Marcela, Gordana Nedić Erjavec, Matea Nikolac Perković, Jorge Sáiz, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Dubravka Švob Štrac, Neven Žarković and Nela Pivac. "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans." Free Radical Biology and Medicine 162 (2021): 636-641. https://doi.org/10.1016/j.freeradbiomed.2020.11.024

Konjevod, M., et al. (2021) 'Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans', Free Radical Biology and Medicine, 162, pp. 636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

Konjevod M, Nedić Erjavec G, Nikolac Perković M, Sáiz J, Tudor L, Uzun S, and sur.. Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans. Free Radical Biology and Medicine [Internet]. 2021 January [cited 2024 November 29];162:636-641. doi: 10.1016/j.freeradbiomed.2020.11.024

M. Konjevod, et al., "Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans", Free Radical Biology and Medicine, vol. 162, pp. 636-641, January 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:993259. [Accessed: 29 November 2024]

Metadata
Title (english)Metabolomics in posttraumatic stress disorder: Untargeted metabolomic analysis of plasma samples from Croatian war veterans
AuthorMarcela Konjevod
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perković
AuthorJorge Sáiz
AuthorLucija Tudor
AuthorSuzana Uzun
AuthorOliver Kozumplik
AuthorDubravka Švob Štrac
AuthorNeven Žarković
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Posttraumatic stress disorder (PTSD) is a severe, multifactorial and debilitating neuropsychiatric disorder, which can develop in a subset of individuals as a result of the exposure to severe stress or trauma. Such traumatic experiences have a major impact on molecular, biochemical and cellular systems, causing psychological and somatic alterations that affect the whole organism. Although the etiology of PTSD is still unclear, it seems to involve complex interaction between various biological genetic and environmental factors. Metabolomics, as one of the rapidly developing "omics" techniques, might be a useful tool for determining altered metabolic pathways and stress-related metabolites as new potential biomarkers of PTSD. The aim of our study was to identify metabolites whose altered levels allow us to differentiate between patients with PTSD and healthy control individuals. The study included two cohorts. The first, exploratory, group included 50 Croatian veterans with PTSD and 50 healthy control subjects, whereas a validation group consisted of 52 veterans with PTSD and 52 control subjects. The metabolomic analysis of plasma samples was conducted using liquid chromatography coupled with mass spectrometry (LC-MS), as well as gas chromatography coupled with mass spectrometry (GC-MS). The LC-MS analysis determined significantly different levels of two glycerophospholipids, PE(18:1/0:0) and PC(18:1/0:0), between control subjects and PTSD patients in both cohorts. The altered metabolites might play a role in multiple cellular processes, including inflammation, mitochondrial dysfunction, membrane breakdown, oxidative stress and neurotoxicity, which could be associated with PTSD pathogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleFree Radical Biology and Medicine
Numberingvol. 162, pp. 636-641
p-ISSN0891-5849
e-ISSN1873-4596
DOIhttps://doi.org/10.1016/j.freeradbiomed.2020.11.024
URN:NBNurn:nbn:hr:105:993259
Publication2021-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0891584920316373
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-02-01
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-05-20 08:05:34