Neonatal liver failure, the failure of the synthetic function of the liver within 28 days of birth, is relatively rare, but unfortunately carries a high mortality rate. There are many different aetiologies of neonatal liver failure, ranging from haematological malignancies to viral infections, from inborn errors of metabolism to drug toxicity. This case review will explore neonatal liver failure due to gestational alloimmune liver disease as seen in three patient families. In addition, prevention of gestational alloimmune liver disease in subsequent pregnancies and the successful birth of healthy or gestational alloimmune liver diseaseunaffected siblings to the parents of the aforementioned gestational alloimmune liver disease-affected patients will be discussed. Family 1’s first born, soon after birth, showed signs of acute liver failure. He received a partial liver transplant from his father, but despite all efforts, died at five months of age from neonatal liver failure as a result of neonatal haemochromatosis. The mother fell pregnant again and, in order to prevent gestational alloimmune liver disease in the second pregnancy, received intravenous immunoglobulin therapy. As a result, a female infant was born with minor complications, but was deemed healthy soon afterwards. Family 2 had two previous children that had died, soon after birth, from neonatal liver failure caused by neonatal haemochromatosis, in addition to two early spontaneous abortions. While in her fifth pregnancy, the mother received intravenous immunoglobulin treatment, and despite some initial mild hepatic dysfunction at birth, following treatment with intravenous immunoglobulin and phototherapy, a healthy baby boy was discharged soon after admission. Family 3’s first child was born prematurely and, at birth, was in haemorrhagic shock due to jejunal perforation and apparent disseminated intravascular coagulation. Despite all therapeutic and surgical interventions, the patient died one month after birth. A year later, the mother fell pregnant and received preventative intravenous immunoglobulin. Although the pregnancy was laden with complications, a healthy male infant was born without any organ dysfunction.