prikaz prve stranice dokumenta Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
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Scientific paper - Original scientific paper
Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
Cells, 10 (2021), 2; 415. https://doi.org/10.3390/cells10020415
Miškić, Terezija; Kostović, Ivica; Rašin, Mladen-Roko; Krsnik, Željka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Miškić, T., Kostović, I., Rašin, M. R. & Krsnik, Ž. (2021). Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain. Cells, 10. (2). doi: 10.3390/cells10020415

Miškić, Terezija, et al. "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain." Cells, vol. 10, no. 2, 2021. https://doi.org/10.3390/cells10020415

Miškić, Terezija, Ivica Kostović, Mladen Roko Rašin and Željka Krsnik. "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain." Cells 10, no. 2 (2021). https://doi.org/10.3390/cells10020415

Miškić, T., et al. (2021) 'Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain', Cells, 10(2). doi: 10.3390/cells10020415

Miškić T, Kostović I, Rašin MR, Krsnik Ž. Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain. Cells [Internet]. 2021 February 17 [cited 2024 December 24];10(2). doi: 10.3390/cells10020415

T. Miškić, I. Kostović, M. R. Rašin and Ž. Krsnik, "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain", Cells, vol. 10, no. 2, February 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:038706. [Accessed: 24 December 2024]

Metadata
Title (english)Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
AuthorTerezija Miškić
AuthorIvica Kostović
AuthorMladen-Roko Rašin
AuthorŽeljka Krsnik
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Cut-Like Homeobox 2 (Cux2) is a transcription factor involved in dendrite and spine development, and synapse formation of projection neurons placed in mouse upper neocortical layers. Therefore, Cux2 is often used as an upper layer marker in the mouse brain. However, expression of its orthologue CUX2 remains unexplored in the human fetal neocortex. Here, we show that CUX2 protein is expressed in transient compartments of developing neocortical anlage during the main fetal phases of neocortical laminar development in human brain. During the early fetal phase when neurons of the upper cortical layers are still radially migrating to reach their final place in the cortical anlage, CUX2 was expressed in the marginal zone (MZ), deep cortical plate, and pre-subplate. During midgestation, CUX2 was still expressed in the migrating upper cortical neurons as well as in the subplate (SP) and MZ neurons. At the term age, CUX2 was expressed in the gyral white matter along with its expected expression in the upper layer neurons. In sum, CUX2 was expressed in migratory neurons of prospective superficial layers and in the diverse subpopulation of transient postmigratory SP and MZ neurons. Therefore, our findings indicate that CUX2 is a novel marker of distinct transient, but critical histogenetic events during corticogenesis. Given the Cux2 functions reported in animal models, our data further suggest that the expression of CUX2 in postmigratory SP and MZ neurons is associated with their unique dendritic and synaptogenesis characteristics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCells
Numberingvol. 10, no. 2, 415
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells10020415
URN:NBNurn:nbn:hr:105:038706
Publication2021-02-17
Document URLhttps://www.mdpi.com/2073-4409/10/2/415
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-06-25 09:09:08