prikaz prve stranice dokumenta Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience
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Scientific paper - Original scientific paper
Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience
Clinical Neurology and Neurosurgery, 201 (2021); 106426. https://doi.org/10.1016/j.clineuro.2020.106426
Bujan Kovač, Andreja; Petelin Gadže, Željka; Radoš, Milan; Krbot Skorić, Magdalena; Mrak, Goran; Nemir, Jakob; Milošević, Milan; Hajnšek, Sanja

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Bujan Kovač, A., Petelin Gadže, Ž., Radoš, M., Krbot Skorić, M., Mrak, G., Nemir, J. ... Hajnšek, S. (2021). Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience. Clinical Neurology and Neurosurgery, 201.. doi: 10.1016/j.clineuro.2020.106426

Bujan Kovač, Andreja, et al. "Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience." Clinical Neurology and Neurosurgery, vol. 201, 2021. https://doi.org/10.1016/j.clineuro.2020.106426

Bujan Kovač, Andreja, Željka Petelin Gadže, Milan Radoš, Magdalena Krbot Skorić, Goran Mrak, Jakob Nemir, Milan Milošević and Sanja Hajnšek. "Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience." Clinical Neurology and Neurosurgery 201 (2021). https://doi.org/10.1016/j.clineuro.2020.106426

Bujan Kovač, A., et al. (2021) 'Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience', Clinical Neurology and Neurosurgery, 201. doi: 10.1016/j.clineuro.2020.106426

Bujan Kovač A, Petelin Gadže Ž, Radoš M, Krbot Skorić M, Mrak G, Nemir J, and sur.. Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience. Clinical Neurology and Neurosurgery [Internet]. 2021 February [cited 2024 November 26];201. doi: 10.1016/j.clineuro.2020.106426

A. Bujan Kovač, et al., "Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience", Clinical Neurology and Neurosurgery, vol. 201, February 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900886. [Accessed: 26 November 2024]

Metadata
Title (english)Brain MRI post-processing with MAP07 in the preoperative evaluation of patients with pharmacoresistant epilepsy – Croatian single centre experience
AuthorAndreja Bujan Kovač
AuthorŽeljka Petelin Gadže
AuthorMilan Radoš
AuthorMagdalena Krbot Skorić
AuthorGoran Mrak
AuthorJakob Nemir
AuthorMilan Milošević
AuthorSanja Hajnšek
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Environmental and Occupational Health)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Occupational and Sports Medicine
Abstract (english)
Objective: This study aimed to determine the role of brain MRI post-processing method MAP07 (Morphometric Analysis Program) in detecting epileptogenic brain lesions in patients with pharmacoresistant epilepsy (PE). MAP07 is a sophisticated diagnostic program that offers several morphometric maps and facilitates the detection and localization of hippocampal sclerosis (HS), focal cortical dysplasias (FCD), and other types of cortical malformations, which could be undetected by conventional visual MRI analysis (CVA). ----- Methods: 120 patients aged > 16 years with PE have been recruited. 3 T MRI was performed according to epilepsy imaging protocol followed by image postprocessing with a fully automated MATLAB script, MAP07, by applying SPM5 algorithms. Statistical analysis was performed in IBM SPSS Statistics, version 25.0. ----- Results: Analysis in our patients showed a high sensitivity of MAP07 with low specificity and with a high proportion of false-positive patients. After MRI analysis, out of 120 patients, 32 were found to have no structural abnormalities by conventional visual analysis in whom after MAP07 in 5 patients structural lesions were found (in one HS, in one FCD, in two perinatal vascular lesions, and in one hippocampal hyperintensity). There was a quite high overall coincidence of the findings of MAP07 and MRI for the detection of FCD, HS, perinatal ischemia/chronic vascular lesions, heterotopias, and polymicrogyria (kappa coefficient above 0.700). ----- Conclusions: MAP07 analysis is a useful, additional, and automated method that may guide re-evaluation of MRI by highlighting suspicious cortical regions, as a complementary method to CVA, by enhancing the visualization of cortical malformations and lesions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleClinical Neurology and Neurosurgery
Numberingvol. 201, 106426
p-ISSN0303-8467
e-ISSN1872-6968
DOIhttps://doi.org/10.1016/j.clineuro.2020.106426
URN:NBNurn:nbn:hr:105:900886
Publication2021-02
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0303846720307691
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-03-01
Terms of useLicence In copyright icon
Created on2021-07-27 07:41:59