AIM: Advances in neonatal medicine has dramatically improved survival rate of pre- term infants that are frequently born with numerous neurodevelopmental disabilities including epileptic seizures and epilepsy. In this dissertation the hypothesis was that localisation of white matter injury is associated with epileptiform EEG changes and neurodevelopmental outcome. ----- MATERIALS AND METHODS: In 64 preterm infants we analyzed EEG, brain MRI and ultrasound and motor d evelopment. We evaluated the relationship of brain white matter lesion with EEG and lesions of certain brain localisation (segment II crossroads, parietal, temporal, occipital lobe, basal ganglia, cerebellum and ventriculomegaly) with epileptic seizu- res and neurodevelopmental outcome. ----- RESULTS: The total number of white matter lesions was in a positive correlation with the pathological EEG findings and epileptic seizures in infants. Infants who did not have visible anterior and posterior crossroads frequen tly had epileptic seizures during newborn period and worse neurodevelopmental outcome. ----- Conclusion: The obtained results indicate that white matter damage is associated with epileptogenesis. Among individual localization, the visibility of segment II as the place where commissural, projection and associative fibers are crossing has a prognostic value for the future neurodevelopmental outcome. Further studies are needed in order to determine the pathogenic factors that contribute to epileptogenesis in infants with white matter lesions.