Cannabis, as common addictive substance, can induce acute psychotic episode. The question is, can it cause psychotic disorder, such as schizophrenia. Chemicals in plant Cannabis sativa, such as Δ9- tetrahydrocannabinol (THC), cannabidiol and cannabinol, are strongly psychoactive and bind to CB1 and CB2 receptors in the brain and consequently influence dopaminergic system. Cannabinoids may, along with other milder symptoms, induce a dysphoric state and, in rare cases after the use of high doses, cause actual psychotic episodes. Schizophrenia is a complex neurodevelopmental disorder characterized by a group of specific symptoms. Doubtless, genetics, neurodevelopmental problems, abnormal connectivity, as well as psychosocial stressors, all contribute to development of schizophrenia. History of cannabis abuse in schizophrenic patients is higher than in general population. Twenty five percent of schizophrenic patients, also have disorder of marihuana consumption. Recent studies have shown that younger patients with first psychotic episode and male patients, more often present with cannabis use disorder. Cannabis use in adolescence increases number of hospitalisations and rehospitalisations, leads to experiencing more positive symptoms and more frequent relapses. An entity „cannabis induced schizophrenia“ is still a matter of many discussions. Reasons of such high rates of cannabis use in schizophrenia are not completely understood. There are few hypotheses about the subject, which include: „self medication- self healing“, increased positive and decreased negative effect of psychoactive substances in those patients, environmental risk factors and dysfunctional reward system. Neuropsychological connection amidst cannabis and schizophrenia is based on interaction of dopamine and brain structure modeling. All things considered, it is important to recognise and treat this condition.