Hodgkin lymphoma (HL) is a hematological neoplasm, mostly affecting lymph nodes. It occurs as a result of clonal transformation of B-lymphocytes and is characterized with Reed-Sternberg cells. Patients usually present with painless lymphadenopathy which can be accompanied with B symptoms including fever, profuse night sweating and weight loss. Treatment depends on stage of disease and it is determined by Ann Arbor classification. Stage I and II represent early favorable or unfavorable disease, while stage III and IV are considered to be advanced. Current treatment is a combination of chemo- and radiotherapy. Recent attempts to omit radiotherapy in early stages of HL by using PET-CT scan were somewhat disappointing. Considering the cure rate of more than 85%, complications of treatment present the most challenging problem today. Complications can manifest as early or late ones. Early complications result from consequences of radiotherapy and chemotherapy and include nausea, vomiting, alopecia, neutropenia, anemia, fatigue, and radiation dermatitis. Long-term survivors are at an increased risk of late effects years after the treatment. Secondary malignancies and cardiovascular diseases are the most important. Other late effects have also been identified, such as subfertility, endocrinal and pulmonary dysfunction, chronic fatigue, muscular atrophy and cognitive impairment. Although, the dose of radiotherapy is reduced with smaller fields and novel irradiation techniques applied, and less alkylating chemotherapeutics is used the late complications have not been reduced over the past two decades. Today, we witness complications following chemotherapy and especially radiotherapy that was used 20-30 years ago. Conversely, the complications of todays treatment will be seen in future. The role of physician is to follow the survivors, encourage the patients to promote healthy lifestyle and avoid risk factors such as smoking. In addition, the screening programs for early detection of malignancies and cardiovascular diseases should be performed.