prikaz prve stranice dokumenta Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
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Scientific paper - Original scientific paper
Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
Croatian Medical Journal, 62 (2021), 4; 338-346. https://doi.org/10.3325/cmj.2021.62.338
Matas, Marijana; Sotošek, Vlatka; Kozmar, Ana; Likić, Robert; Mrak, Goran; Nagy, Bálint; Sekulić, Ante

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Matas, M., Sotošek, V., Kozmar, A., Likić, R., Mrak, G., Nagy, B. & Sekulić, A. (2021). Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. Croatian Medical Journal, 62. (4), 338-346. doi: 10.3325/cmj.2021.62.338

Matas, Marijana, et al. "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial." Croatian Medical Journal, vol. 62, no. 4, 2021, pp. 338-346. https://doi.org/10.3325/cmj.2021.62.338

Matas, Marijana, Vlatka Sotošek, Ana Kozmar, Robert Likić, Goran Mrak, Bálint Nagy and Ante Sekulić. "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial." Croatian Medical Journal 62, no. 4 (2021): 338-346. https://doi.org/10.3325/cmj.2021.62.338

Matas, M., et al. (2021) 'Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial', Croatian Medical Journal, 62(4), pp. 338-346. doi: 10.3325/cmj.2021.62.338

Matas M, Sotošek V, Kozmar A, Likić R, Mrak G, Nagy B, and sur.. Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. Croatian Medical Journal [Internet]. 2021 August 31 [cited 2024 November 22];62(4):338-346. doi: 10.3325/cmj.2021.62.338

M. Matas, et al., "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial", Croatian Medical Journal, vol. 62, no. 4, pp. 338-346, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:576102. [Accessed: 22 November 2024]

Metadata
Title (english)Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
AuthorMarijana Matas
AuthorVlatka Sotošek
AuthorAna Kozmar
AuthorRobert Likić
AuthorGoran Mrak
AuthorBálint Nagy
AuthorAnte Sekulić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To compare the effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on pro-inflammatory cytokine concentrations in patients with non-ruptured brain aneurysms undergoing elective open surgery. ----- Methods: This parallel, randomized, controlled, open-label trial was conducted at Clinical Hospital Center Zagreb between March 2019 and March 2020. At the beginning of anesthesia, lidocaine group received 40 mg of 2% lidocaine for laryngotracheal topical anesthesia and 4 mg/kg for the scalp block. Control group underwent general anesthesia only. Plasma concentrations of IL-6, TNF-α, and IL-1β were measured before anesthesia (S0); at the incision (S1); at the end of surgery (S2); 24 hours postoperatively (S3). Cerebrospinal fluid (CSF) cytokine concentrations were measured at the incision (L1) and the end of surgery (L2). ---- Results: Forty patients (each group, 20) were randomized; 37 were left in the final analysis. IL-6 plasma concentrations increased significantly compared with baseline at S3 in lidocaine group, and at S2 and S3 in control group. In both groups, changes in TNF-α and IL-1β were not significant. CSF cytokine concentrations in lidocaine group did not change significantly; in control group IL-6 and IL-1β were significantly higher at L2 than at L1. CSF IL-6 in control group significantly increased at L2, but TNF-α and IL-1β did not. No differences in clinical outcome and complication rates were observed. ----- Conclusion: Adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia might attenuate CSF IL-6 concentration increase in patients with brain aneurysm.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 62, no. 4, pp. 338-346
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2021.62.338
URN:NBNurn:nbn:hr:105:576102
Publication2021-08-31
Document URLhttp://www.cmj.hr/2021/62/4/34472736.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-09-21 07:46:27