The prevalence of autoimmune diseases has increased in the last decade. In order to deal with the escalating figures, we need to know how to recognize them. One of the first indicators which can be noticed is when the condition appears on the skin, especially in the area of the face, due to its obvious and easily accessible location. This thesis deals with four important autoimmune diseases that, among other areas on and in the body, affects the face. They have been chosen due to their prevalence, deleterious effects imposed on the body and quality of life, but also, due to the convenient early symptoms developing on the skin; possibility for the early recognition, diagnosis and treatment. The autoimmune disorders which are about to be discussed in this thesis are: dermatomyositis, lupus erythematosus, morphea and pemphigus vulgaris. Dermatomyositis is a rare inflammatory disease. It belongs to the group of inflammatory myopathies. It commonly affects the muscles with preceding skin symptoms. The rash that appears is red to purple in color and is usually found on the face (commonly on the eyelids, nose and cheeks) and on the knuckles of the hands. Dermatomyositis can affect adults as well as children. Lupus erythematosus has a potential to affect many systems in the body, however skin involvement has been perceived as an isolated condition and therefore subjected to different handling. Cutaneous lupus erythematosus is a skin disease which may occur independent of or as an accompanying expression of systemic lupus erythematosus. It is divided into three main subtypes; acute cutaneous lupus erythematosus (ACLE), subacute cutaneous lupus erythematosus (SCLE), and chronic cutaneous lupus erythematosus (CCLE). The types are characterized by photosensitivity and have a predilection to affect the face and sun exposed areas of the skin. Morphea, a designated term for localized scleroderma, is a chronic condition of unknown etiology. It is the most common form of scleroderma, characterized by thickening of the skin. It can be further divided into subtypes, each with a different clinical manifestation and level of connective tissue involved. Each of the subtypes can affect the face. Pemphigus vulgaris is the most common type in the group of pemphigus diseases. It is rare and causes painful blistering on the skin and mucous membranes. Blisters have tendency to spread widely and when ruptured, may become infected. Diagnosis is made on the basis of clinical picture and laboratory tests, among which direct immunofluorescence represents the golden standard. Treatment includes systemic corticosteroids and adjuvant therapy, most often azathioprine. Rituximab has been used more often in recent years.