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Scientific paper - Review paper
Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview
Pharmacogenomics and Personalized Medicine, 14 (2021); 631-653. https://doi.org/10.2147/PGPM.S284615
Švob Štrac, Dubravka; Konjevod, Marcela; Šagud, Marina; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Vuić, Barbara; Šimić, Goran; Vukić, Vana; Mimica, Ninoslav; Pivac, Nela

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Švob Štrac, D., Konjevod, M., Šagud, M., Nikolac Perković, M., Nedić Erjavec, G., Vuić, B. ... Pivac, N. (2021). Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview. Pharmacogenomics and Personalized Medicine, 14., 631-653. doi: 10.2147/PGPM.S284615

Švob Štrac, Dubravka, et al. "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview." Pharmacogenomics and Personalized Medicine, vol. 14, 2021, pp. 631-653. https://doi.org/10.2147/PGPM.S284615

Švob Štrac, Dubravka, Marcela Konjevod, Marina Šagud, Matea Nikolac Perković, Gordana Nedić Erjavec, Barbara Vuić, Goran Šimić, Vana Vukić, Ninoslav Mimica and Nela Pivac. "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview." Pharmacogenomics and Personalized Medicine 14 (2021): 631-653. https://doi.org/10.2147/PGPM.S284615

Švob Štrac, D., et al. (2021) 'Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview', Pharmacogenomics and Personalized Medicine, 14, pp. 631-653. doi: 10.2147/PGPM.S284615

Švob Štrac D, Konjevod M, Šagud M, Nikolac Perković M, Nedić Erjavec G, Vuić B, and sur.. Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview. Pharmacogenomics and Personalized Medicine [Internet]. 2021 May 28 [cited 2025 April 12];14:631-653. doi: 10.2147/PGPM.S284615

D. Švob Štrac, et al., "Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview", Pharmacogenomics and Personalized Medicine, vol. 14, pp. 631-653, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:099729. [Accessed: 12 April 2025]

Metadata
Title (english)Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview
AuthorDubravka Švob Štrac
AuthorMarcela Konjevod
AuthorMarina Šagud
AuthorMatea Nikolac Perković
AuthorGordana Nedić Erjavec
AuthorBarbara Vuić
AuthorGoran Šimić
AuthorVana Vukić
AuthorNinoslav Mimica
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Alzheimer's disease (AD) is a progressive, complex, and multifactorial neurodegenerative disorder, still without effective and stable therapeutic strategies. Currently, available medications for AD are based on symptomatic therapy, which include acetylcholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonist. Additionally, medications such as antipsychotic drugs, antidepressants, sedative, and hypnotic agents, and mood stabilizers are used for the management of... More behavioral and psychological symptoms of dementia (BPSD). Clinical research has been extensively investigated treatments focusing on the hallmark pathology of AD, including the amyloid deposition, tau hyperphosphorylation, neuroinflammation, and vascular changes; however, so far without success, as all new potential drugs failed to show significant clinical benefit. The underlying heterogeneous etiology and diverse symptoms of AD suggest that a precision medicine strategy is required, which would take into account the complex genetic, epigenetic, and environmental landscape of each AD patient. The article provides a comprehensive overview of the literature on AD, the current and potential therapy of both cognitive symptoms as well as BPSD, with a special focus on gut microbiota and epigenetic modifications as new emerging drug targets. Their specific patterns could represent the basis for novel individually tailored approaches aimed to optimize precision medicine strategies for AD prevention and treatment. However, the successful application of precision medicine to AD demands a further extensive research of underlying pathological processes, as well as clinical and biological complexity of this multifactorial neurodegenerative disorder. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePharmacogenomics and Personalized Medicine
Numberingvol. 14, pp. 631-653
e-ISSN1178-7066
DOIhttps://doi.org/10.2147/PGPM.S284615
URN:NBNurn:nbn:hr:105:099729
Publication2021-05-28
ProjectNumber: IP-2019-04-6100
Title (croatian): Terapijski potencijal neurosteroida i neurotrofina u demenciji
Title (english): Therapeutic potential of neurosteroids and neurotrophins in dementia
Acronym: TePoNeDe
Leader: Dubravka Švob Štrac
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.dovepress.com/personalizing-the-care-and-treatment-of-alzheimers-disease-an-overview-peer-reviewed-fulltext-article-PGPM
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2021-10-14 09:04:11
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